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Ovarian tissue cryopreservation: Low usage rates and high live‐birth rate after transplantation
INTRODUCTION: The likelihood of survival after cancer treatment among young women with cancer has increased considerably, quality of life after treatment has drawn more attention. However, in young fertile women, fertility preservation is an important issue with regard to quality of life. One of the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003842/ https://www.ncbi.nlm.nih.gov/pubmed/31538662 http://dx.doi.org/10.1111/aogs.13735 |
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author | Hoekman, Ellen J. Louwe, Leoni A. Rooijers, Maxime van der Westerlaken, Lucette A. J. Klijn, Nicole F. Pilgram, Gonneke S. K. de Kroon, Cornelis D. Hilders, Carina G. J. M. |
author_facet | Hoekman, Ellen J. Louwe, Leoni A. Rooijers, Maxime van der Westerlaken, Lucette A. J. Klijn, Nicole F. Pilgram, Gonneke S. K. de Kroon, Cornelis D. Hilders, Carina G. J. M. |
author_sort | Hoekman, Ellen J. |
collection | PubMed |
description | INTRODUCTION: The likelihood of survival after cancer treatment among young women with cancer has increased considerably, quality of life after treatment has drawn more attention. However, in young fertile women, fertility preservation is an important issue with regard to quality of life. One of the options of fertility preservation is ovarian tissue cryopreservation. The purpose of this follow‐up study is to present our clinical experiences and evaluate the long‐term follow up of ovarian cryopreservation to improve future patient selection. MATERIAL AND METHODS: From July 2002 to December 2015 at the Leiden University Hospital, the Netherlands, 69 young women underwent ovarian tissue cryopreservation when they were at risk of iatrogenic premature ovarian insufficiency. Follow‐up data with regard to ovarian function were obtained until October 2018, from medical records and questionnaires. RESULTS: Of the 69 women in whom ovarian tissue cryopreservation was performed, 12 died (15.9%), 57 were approached to participate, of which 6 were lost to follow up. The indications for ovarian tissue cryopreservation were malignant (81.1%) and benign (18.9%) diseases in which gonadotoxic treatment was scheduled. In total, twenty women (39.2%) are known to have premature ovarian insufficiency due to gonadotoxic treatment. Fifteen women conceived spontaneously, and delivered 25 babies. In this cohort, the usage rate of autotransplantation is 8.7% (7/69). In total, nine autotransplantations of cryopreserved ovarian tissue were performed in seven patients (of which 1 ovarian tissue cryopreservation was performed in another hospital) after which 6 babies were born to four women, giving a live‐birth rate of 57%. CONCLUSIONS: Ovarian tissue cryopreservation followed by autotransplantation is an effective method to restore fertility (live‐birth rate of 57%). The usage rate of 8.7% (6/69) indicates that more knowledge about the risk of premature ovarian insufficiency after gonadotoxic treatment is needed to be able to offer ovarian tissue cryopreservation more selectively. |
format | Online Article Text |
id | pubmed-7003842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70038422020-02-11 Ovarian tissue cryopreservation: Low usage rates and high live‐birth rate after transplantation Hoekman, Ellen J. Louwe, Leoni A. Rooijers, Maxime van der Westerlaken, Lucette A. J. Klijn, Nicole F. Pilgram, Gonneke S. K. de Kroon, Cornelis D. Hilders, Carina G. J. M. Acta Obstet Gynecol Scand Fertility INTRODUCTION: The likelihood of survival after cancer treatment among young women with cancer has increased considerably, quality of life after treatment has drawn more attention. However, in young fertile women, fertility preservation is an important issue with regard to quality of life. One of the options of fertility preservation is ovarian tissue cryopreservation. The purpose of this follow‐up study is to present our clinical experiences and evaluate the long‐term follow up of ovarian cryopreservation to improve future patient selection. MATERIAL AND METHODS: From July 2002 to December 2015 at the Leiden University Hospital, the Netherlands, 69 young women underwent ovarian tissue cryopreservation when they were at risk of iatrogenic premature ovarian insufficiency. Follow‐up data with regard to ovarian function were obtained until October 2018, from medical records and questionnaires. RESULTS: Of the 69 women in whom ovarian tissue cryopreservation was performed, 12 died (15.9%), 57 were approached to participate, of which 6 were lost to follow up. The indications for ovarian tissue cryopreservation were malignant (81.1%) and benign (18.9%) diseases in which gonadotoxic treatment was scheduled. In total, twenty women (39.2%) are known to have premature ovarian insufficiency due to gonadotoxic treatment. Fifteen women conceived spontaneously, and delivered 25 babies. In this cohort, the usage rate of autotransplantation is 8.7% (7/69). In total, nine autotransplantations of cryopreserved ovarian tissue were performed in seven patients (of which 1 ovarian tissue cryopreservation was performed in another hospital) after which 6 babies were born to four women, giving a live‐birth rate of 57%. CONCLUSIONS: Ovarian tissue cryopreservation followed by autotransplantation is an effective method to restore fertility (live‐birth rate of 57%). The usage rate of 8.7% (6/69) indicates that more knowledge about the risk of premature ovarian insufficiency after gonadotoxic treatment is needed to be able to offer ovarian tissue cryopreservation more selectively. John Wiley and Sons Inc. 2019-10-08 2020-02 /pmc/articles/PMC7003842/ /pubmed/31538662 http://dx.doi.org/10.1111/aogs.13735 Text en © 2019 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Fertility Hoekman, Ellen J. Louwe, Leoni A. Rooijers, Maxime van der Westerlaken, Lucette A. J. Klijn, Nicole F. Pilgram, Gonneke S. K. de Kroon, Cornelis D. Hilders, Carina G. J. M. Ovarian tissue cryopreservation: Low usage rates and high live‐birth rate after transplantation |
title | Ovarian tissue cryopreservation: Low usage rates and high live‐birth rate after transplantation |
title_full | Ovarian tissue cryopreservation: Low usage rates and high live‐birth rate after transplantation |
title_fullStr | Ovarian tissue cryopreservation: Low usage rates and high live‐birth rate after transplantation |
title_full_unstemmed | Ovarian tissue cryopreservation: Low usage rates and high live‐birth rate after transplantation |
title_short | Ovarian tissue cryopreservation: Low usage rates and high live‐birth rate after transplantation |
title_sort | ovarian tissue cryopreservation: low usage rates and high live‐birth rate after transplantation |
topic | Fertility |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003842/ https://www.ncbi.nlm.nih.gov/pubmed/31538662 http://dx.doi.org/10.1111/aogs.13735 |
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