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Converting F(ENO) by different flows to standard flow F(ENO)

In clinical practice, assessment of expiratory nitric oxide (F(ENO)) may reveal eosinophilic airway inflammation in asthmatic and other pulmonary diseases. Currently, measuring of F(ENO) is standardized to exhaled flow level of 50 ml s(−1), since the expiratory flow rate affects the F(ENO) results....

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Autores principales: Lassmann‐Klee, Paul G., Lehtimäki, Lauri, Lindholm, Tuula, Malmberg, Leo Pekka, Sovijärvi, Anssi R.A., Piirilä, Päivi Liisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003879/
https://www.ncbi.nlm.nih.gov/pubmed/31058423
http://dx.doi.org/10.1111/cpf.12574
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author Lassmann‐Klee, Paul G.
Lehtimäki, Lauri
Lindholm, Tuula
Malmberg, Leo Pekka
Sovijärvi, Anssi R.A.
Piirilä, Päivi Liisa
author_facet Lassmann‐Klee, Paul G.
Lehtimäki, Lauri
Lindholm, Tuula
Malmberg, Leo Pekka
Sovijärvi, Anssi R.A.
Piirilä, Päivi Liisa
author_sort Lassmann‐Klee, Paul G.
collection PubMed
description In clinical practice, assessment of expiratory nitric oxide (F(ENO)) may reveal eosinophilic airway inflammation in asthmatic and other pulmonary diseases. Currently, measuring of F(ENO) is standardized to exhaled flow level of 50 ml s(−1), since the expiratory flow rate affects the F(ENO) results. To enable the comparison of F(ENO) measured with different expiratory flows, we firstly aimed to establish a conversion model to estimate F(ENO) at the standard flow level, and secondly, validate it in five external populations. F(ENO) measurements were obtained from 30 volunteers (mixed adult population) at the following multiple expiratory flow rates: 50, 30, 100 and 300 ml s(−1), after different mouthwash settings, and a conversion model was developed. We tested the conversion model in five populations: healthy adults, healthy children, and patients with COPD, asthma and alveolitis. F(ENO) conversions in the mixed adult population, in healthy adults and in children, showed the lowest deviation between estimated [Formula: see text] from 100 ml s(−1) and measured F(ENO) at 50 mL s(−1): −0·28 ppb, −0·44 ppb and 0·27 ppb, respectively. In patients with COPD, asthma and alveolitis, the deviation was −1·16 ppb, −1·68 ppb and 1·47 ppb, respectively. We proposed a valid model to convert F(ENO) in healthy or mixed populations, as well as in subjects with obstructive pulmonary diseases and found it suitable for converting F(ENO) measured with different expiratory flows to the standard flow in large epidemiological data, but not on individual level. In conclusion, a model to convert F(ENO) from different flows to the standard flow was established and validated.
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spelling pubmed-70038792020-02-11 Converting F(ENO) by different flows to standard flow F(ENO) Lassmann‐Klee, Paul G. Lehtimäki, Lauri Lindholm, Tuula Malmberg, Leo Pekka Sovijärvi, Anssi R.A. Piirilä, Päivi Liisa Clin Physiol Funct Imaging Original Articles In clinical practice, assessment of expiratory nitric oxide (F(ENO)) may reveal eosinophilic airway inflammation in asthmatic and other pulmonary diseases. Currently, measuring of F(ENO) is standardized to exhaled flow level of 50 ml s(−1), since the expiratory flow rate affects the F(ENO) results. To enable the comparison of F(ENO) measured with different expiratory flows, we firstly aimed to establish a conversion model to estimate F(ENO) at the standard flow level, and secondly, validate it in five external populations. F(ENO) measurements were obtained from 30 volunteers (mixed adult population) at the following multiple expiratory flow rates: 50, 30, 100 and 300 ml s(−1), after different mouthwash settings, and a conversion model was developed. We tested the conversion model in five populations: healthy adults, healthy children, and patients with COPD, asthma and alveolitis. F(ENO) conversions in the mixed adult population, in healthy adults and in children, showed the lowest deviation between estimated [Formula: see text] from 100 ml s(−1) and measured F(ENO) at 50 mL s(−1): −0·28 ppb, −0·44 ppb and 0·27 ppb, respectively. In patients with COPD, asthma and alveolitis, the deviation was −1·16 ppb, −1·68 ppb and 1·47 ppb, respectively. We proposed a valid model to convert F(ENO) in healthy or mixed populations, as well as in subjects with obstructive pulmonary diseases and found it suitable for converting F(ENO) measured with different expiratory flows to the standard flow in large epidemiological data, but not on individual level. In conclusion, a model to convert F(ENO) from different flows to the standard flow was established and validated. John Wiley and Sons Inc. 2019-06-03 2019-09 /pmc/articles/PMC7003879/ /pubmed/31058423 http://dx.doi.org/10.1111/cpf.12574 Text en © 2019 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Lassmann‐Klee, Paul G.
Lehtimäki, Lauri
Lindholm, Tuula
Malmberg, Leo Pekka
Sovijärvi, Anssi R.A.
Piirilä, Päivi Liisa
Converting F(ENO) by different flows to standard flow F(ENO)
title Converting F(ENO) by different flows to standard flow F(ENO)
title_full Converting F(ENO) by different flows to standard flow F(ENO)
title_fullStr Converting F(ENO) by different flows to standard flow F(ENO)
title_full_unstemmed Converting F(ENO) by different flows to standard flow F(ENO)
title_short Converting F(ENO) by different flows to standard flow F(ENO)
title_sort converting f(eno) by different flows to standard flow f(eno)
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003879/
https://www.ncbi.nlm.nih.gov/pubmed/31058423
http://dx.doi.org/10.1111/cpf.12574
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