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Highly stereoselective nickel-catalyzed difluoroalkylation of aryl ketones to tetrasubstituted monofluoroalkenes and quaternary alkyl difluorides

A nickel-catalyzed difluoroalkylation of α-C–H bonds of aryl ketones to furnish highly stereo-defined tetrasubstituted monofluoroalkenes or quaternary alkyl difluorides from secondary or tertiary ketones, respectively, has been established. Mechanistic investigations indicated that these C–H fluoroa...

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Detalles Bibliográficos
Autores principales:	Li, Chao, Cao, Yi-Xuan, Jin, Ruo-Xing, Bian, Kang-Jie, Qin, Zi-Yang, Lan, Quan, Wang, Xi-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003883/ https://www.ncbi.nlm.nih.gov/pubmed/32055314 http://dx.doi.org/10.1039/c9sc02806d

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