Cargando…

Combining In Vitro Data and Physiologically Based Kinetic Modeling Facilitates Reverse Dosimetry to Define In Vivo Dose–Response Curves for Bixin‐ and Crocetin‐Induced Activation of PPARγ in Humans

SCOPE: It is investigated whether at realistic dietary intake bixin and crocetin could induce peroxisome proliferator‐activated receptor γ (PPARγ)‐mediated gene expression in humans using a combined in vitro–in silico approach. METHODS AND RESULTS: Concentration–response curves obtained from in vitr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suparmi, Suparmi, de Haan, Laura, Spenkelink, Albertus, Louisse, Jochem, Beekmann, Karsten, Rietjens, Ivonne M. C. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003908/ https://www.ncbi.nlm.nih.gov/pubmed/31846197 http://dx.doi.org/10.1002/mnfr.201900880

Ejemplares similares

Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach
por: Suparmi, Suparmi, et al.
Publicado: (2020)

Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach
por: Abdullah, Rozaini, et al.
Publicado: (2020)

An in vitromodel to quantify interspecies differences in kinetics for intestinal microbial bioactivation and detoxification of zearalenone
por: Mendez-Catala, Diana M., et al.
Publicado: (2020)

The potential health effects of dietary phytoestrogens
por: Rietjens, Ivonne M C M, et al.
Publicado: (2016)

Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling
por: Ning, Jia, et al.
Publicado: (2017)

Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf
por: Hiben, Mebrahtom Gebrelibanos, et al.
Publicado: (2020)

Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data
por: Zhang, Mengying, et al.
Publicado: (2017)

Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S‐Equol and Its Consequences for ERα Activation
por: Wang, Qianrui, et al.
Publicado: (2020)

Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry
por: Omwenga, Isaac, et al.
Publicado: (2021)

Effects of Maerua subcordata (Gilg) DeWolf on electrophile-responsive element (EpRE)-mediated gene expression in vitro
por: Gebrelibanos Hiben, Mebrahtom, et al.
Publicado: (2019)

Utilization of Biang Fish Flour (Ilisha elongata) as an Enrichment Material for Sago Noodles Nutrient Value
por: Suparmi, Suparmi, et al.
Publicado: (2022)

Comparisons of Curative Effects of Chlorophyll from Sauropus androgynus (L) Merr Leaf Extract and Cu-Chlorophyllin on Sodium Nitrate-Induced Oxidative Stress in Rats
por: Suparmi, Suparmi, et al.
Publicado: (2016)

Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population
por: Zhao, Shensheng, et al.
Publicado: (2019)

Socio-economic, demographic and geographic correlates of cigarette smoking among Indonesian adolescents: results from the 2013 Indonesian Basic Health Research (RISKESDAS) survey
por: Kusumawardani, Nunik, et al.
Publicado: (2018)

Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon
por: Zhao, Shensheng, et al.
Publicado: (2021)

Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols
por: Strikwold, Marije, et al.
Publicado: (2016)

Data source mapping: an essential step for health inequality monitoring
por: Hosseinpoor, Ahmad Reza, et al.
Publicado: (2018)

Subnational regional inequality in the public health development index in Indonesia
por: Suparmi,, et al.
Publicado: (2018)

The Role of Endocrine and Dioxin-Like Activity of Extracts of Petroleum Substances in Developmental Toxicity as Detected in a Panel of CALUX Reporter Gene Assays
por: Kamelia, Lenny, et al.
Publicado: (2018)

Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone
por: Shi, Miaoying, et al.
Publicado: (2020)

Extended evaluation on the ES-D3 cell differentiation assay combined with the BeWo transport model, to predict relative developmental toxicity of triazole compounds
por: Li, Hequn, et al.
Publicado: (2015)

Use of Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Acute Toxicity of Tetrodotoxin in Rodents
por: Noorlander, Annelies, et al.
Publicado: (2022)

Bixin Attenuates High-Fat Diet-Caused Liver Steatosis and Inflammatory Injury through Nrf2/PPARα Signals
por: Tao, Shasha, et al.
Publicado: (2021)

Estrogen receptor alpha (ERα)–mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17β-estradiol (E2)
por: Adam, Aziza Hussein Bakheit, et al.
Publicado: (2020)

Interindividual Differences in Human In Vitro Intestinal Microbial Conversion of Green Tea (‐)‐Epigallocatechin‐3‐O‐Gallate and Consequences for Activation of Nrf2 Mediated Gene Expression
por: Liu, Chen, et al.
Publicado: (2020)

Study of Bohr Mottelson Hamiltonian with minimal length effect for Woods-Saxon potential and its thermodynamic properties
por: Suparmi, A., et al.
Publicado: (2021)

Therapeutic potential of bixin on inflammation: a mini review
por: Shadisvaaran, Saminathan, et al.
Publicado: (2023)

Associations Between Parental Depression and Early Childhood Development in Indonesia: A Cross-sectional Study
por: Saptarini, Ika, et al.
Publicado: (2021)

Crocetin: A Systematic Review
por: Guo, Zi-Liang, et al.
Publicado: (2022)

Use of Physiologically Based Pharmacokinetic Modeling to Predict Human Gut Microbial Conversion of Daidzein to S-Equol
por: Wang, Qianrui, et al.
Publicado: (2021)

Defining a conformational ensemble that directs activation of PPARγ
por: Chrisman, Ian M., et al.
Publicado: (2018)

Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats
por: Moreira, Priscila R, et al.
Publicado: (2014)

Electronic and structural properties of the natural dyes curcumin, bixin and indigo
por: Michels, Leander, et al.
Publicado: (2021)

Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents
por: Zare Jeddi, Maryam, et al.
Publicado: (2018)

Effects of Crocetin Esters and Crocetin from Crocus sativus L. on Aortic Contractility in Rat Genetic Hypertension
por: Llorens, Silvia, et al.
Publicado: (2015)

Delivering Crocetin across the Blood-Brain Barrier by Using γ-Cyclodextrin to Treat Alzheimer’s Disease
por: Wong, Ka Hong, et al.
Publicado: (2020)

The role of metabolism in the developmental toxicity of polycyclic aromatic hydrocarbon‐containing extracts of petroleum substances
por: Kamelia, Lenny, et al.
Publicado: (2019)

The psychological distress of parents is associated with reduced linear growth of children: Evidence from a nationwide population survey
por: Susiloretni, Kun A., et al.
Publicado: (2021)

Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine
por: van Dongen, Katja C. W., et al.
Publicado: (2022)

Adsorption Characteristics of Bixin on Acid- and Alkali-Treated Kaolinite in Aprotic Solvents
por: Rahmalia, Winda, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_c3tp17b9vljuv351q5i1v92eqg