Computer‐Assisted Recombination (CompassR) Teaches us How to Recombine Beneficial Substitutions from Directed Evolution Campaigns

A main remaining challenge in protein engineering is how to recombine beneficial substitutions. Systematic recombination studies show that poorly performing variants are usually obtained after recombination of 3 to 4 beneficial substitutions. This limits researchers in exploiting nature's poten...

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Detalles Bibliográficos
Autores principales: Cui, Haiyang, Cao, Hao, Cai, Haiying, Jaeger, Karl‐Erich, Davari, Mehdi D., Schwaneberg, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003928/
https://www.ncbi.nlm.nih.gov/pubmed/31553080
http://dx.doi.org/10.1002/chem.201903994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003928/
https://www.ncbi.nlm.nih.gov/pubmed/31553080
http://dx.doi.org/10.1002/chem.201903994

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