The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, Which Is Essential for Ribosome Biogenesis

Novel targets are needed for treatment of devastating diseases such as cancer. For decades, natural products have guided innovative therapies by addressing diverse pathways. Inspired by the potent cytotoxic bioactivity of myxobacterial vioprolides A–D, we performed in‐depth studies on their mode of...

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Detalles Bibliográficos
Autores principales: Kirsch, Volker C., Orgler, Christina, Braig, Simone, Jeremias, Irmela, Auerbach, David, Müller, Rolf, Vollmar, Angelika M., Sieber, Stephan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004033/
https://www.ncbi.nlm.nih.gov/pubmed/31658409
http://dx.doi.org/10.1002/anie.201911158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004033/
https://www.ncbi.nlm.nih.gov/pubmed/31658409
http://dx.doi.org/10.1002/anie.201911158

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