TLR5 agonist entolimod reduces the adverse toxicity of TNF while preserving its antitumor effects

Tumor necrosis factor alpha (TNF) is capable of inducing regression of solid tumors. However, TNF released in response to Toll-like receptor 4 (TLR4) activation by bacterial lipopolysaccharide (LPS) is the key mediator of cytokine storm and septic shock that can cause severe tissue damage limiting a...

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Detalles Bibliográficos
Autores principales: Haderski, Gary J., Kandar, Bojidar M., Brackett, Craig M., Toshkov, Ilia M., Johnson, Christopher P., Paszkiewicz, Geraldine M., Natarajan, Venkatesh, Gleiberman, Anatoli S., Gudkov, Andrei V., Burdelya, Lyudmila G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004342/
https://www.ncbi.nlm.nih.gov/pubmed/32027657
http://dx.doi.org/10.1371/journal.pone.0227940

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