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Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development

BACKGROUND: Cytochrome P450 1b1 (Cyp1b1) deletion and dietary retinol deficiency during pregnancy (GVAD) affect perinatal liver functions regulated by Srebp. Cyp1b1 is not expressed in perinatal liver but appears in the E9.5 embryo, close to sites of retinoic acid (RA) signaling. HYPOTHESIS: Paralle...

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Detalles Bibliográficos
Autores principales:	Maguire, Meghan, Larsen, Michele Campaigne, Vezina, Chad M., Quadro, Loredana, Kim, Youn-Kyung, Tanumihardjo, Sherry A., Jefcoate, Colin R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004353/ https://www.ncbi.nlm.nih.gov/pubmed/32027669 http://dx.doi.org/10.1371/journal.pone.0228436

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