Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal

Low protein synthesis is a feature of somatic stem cells that promotes regeneration in multiple tissues. Modest increases in protein synthesis impair stem cell function, but the mechanisms by which this occurs are largely unknown. We determine that low protein synthesis within hematopoietic stem cel...

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Detalles Bibliográficos
Autores principales: Jose, Lorena Hidalgo San, Sunshine, Mary Jean, Dillingham, Christopher H., Chua, Bernadette A., Kruta, Miriama, Hong, Yuning, Hatters, Danny M., Signer, Robert A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004491/
https://www.ncbi.nlm.nih.gov/pubmed/31914399
http://dx.doi.org/10.1016/j.celrep.2019.12.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004491/
https://www.ncbi.nlm.nih.gov/pubmed/31914399
http://dx.doi.org/10.1016/j.celrep.2019.12.003

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