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Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal
Low protein synthesis is a feature of somatic stem cells that promotes regeneration in multiple tissues. Modest increases in protein synthesis impair stem cell function, but the mechanisms by which this occurs are largely unknown. We determine that low protein synthesis within hematopoietic stem cel...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004491/ https://www.ncbi.nlm.nih.gov/pubmed/31914399 http://dx.doi.org/10.1016/j.celrep.2019.12.003 |