Nuclear factor κB -inducing kinase is a diagnostic marker of gastric cancer

Nuclear factor-κB-inducing kinase (NIK) is a new regulator of nuclear factor-κB signaling, which plays an important role in tumorigenesis. This study aimed to examine the expression of NIK in gastric cancer and investigate its clinical significance. Tumor issues were collected from 80 gastric cancer...

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Autores principales: Teng, Hairong, Xue, Liang, Wang, Yuexia, Ding, Xian, Li, Jiaxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
4100
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004655/
https://www.ncbi.nlm.nih.gov/pubmed/32000390
http://dx.doi.org/10.1097/MD.0000000000018864
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author Teng, Hairong
Xue, Liang
Wang, Yuexia
Ding, Xian
Li, Jiaxin
author_facet Teng, Hairong
Xue, Liang
Wang, Yuexia
Ding, Xian
Li, Jiaxin
author_sort Teng, Hairong
collection PubMed
description Nuclear factor-κB-inducing kinase (NIK) is a new regulator of nuclear factor-κB signaling, which plays an important role in tumorigenesis. This study aimed to examine the expression of NIK in gastric cancer and investigate its clinical significance. Tumor issues were collected from 80 gastric cancer patients who received surgery and the diagnosis was confirmed by postoperative pathological analysis. The expression of NIK in gastric cancer tissues and adjacent normal mucosa was detected by immunohistochemical analysis. The associations between NIK expression and clinicopathological features of the patients were further analyzed. NIK expression was significantly higher in gastric cancer tissues than in adjacent normal tissues (P < .05). Furthermore, NIK expression showed significant association with UICC stage, T status, and differentiation, but not with age and gender of gastric cancer patients. NIK is overexpressed in gastric cancer and is a potential diagnostic marker of gastric cancer.
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spelling pubmed-70046552020-02-18 Nuclear factor κB -inducing kinase is a diagnostic marker of gastric cancer Teng, Hairong Xue, Liang Wang, Yuexia Ding, Xian Li, Jiaxin Medicine (Baltimore) 4100 Nuclear factor-κB-inducing kinase (NIK) is a new regulator of nuclear factor-κB signaling, which plays an important role in tumorigenesis. This study aimed to examine the expression of NIK in gastric cancer and investigate its clinical significance. Tumor issues were collected from 80 gastric cancer patients who received surgery and the diagnosis was confirmed by postoperative pathological analysis. The expression of NIK in gastric cancer tissues and adjacent normal mucosa was detected by immunohistochemical analysis. The associations between NIK expression and clinicopathological features of the patients were further analyzed. NIK expression was significantly higher in gastric cancer tissues than in adjacent normal tissues (P < .05). Furthermore, NIK expression showed significant association with UICC stage, T status, and differentiation, but not with age and gender of gastric cancer patients. NIK is overexpressed in gastric cancer and is a potential diagnostic marker of gastric cancer. Wolters Kluwer Health 2020-01-31 /pmc/articles/PMC7004655/ /pubmed/32000390 http://dx.doi.org/10.1097/MD.0000000000018864 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 4100
Teng, Hairong
Xue, Liang
Wang, Yuexia
Ding, Xian
Li, Jiaxin
Nuclear factor κB -inducing kinase is a diagnostic marker of gastric cancer
title Nuclear factor κB -inducing kinase is a diagnostic marker of gastric cancer
title_full Nuclear factor κB -inducing kinase is a diagnostic marker of gastric cancer
title_fullStr Nuclear factor κB -inducing kinase is a diagnostic marker of gastric cancer
title_full_unstemmed Nuclear factor κB -inducing kinase is a diagnostic marker of gastric cancer
title_short Nuclear factor κB -inducing kinase is a diagnostic marker of gastric cancer
title_sort nuclear factor κb -inducing kinase is a diagnostic marker of gastric cancer
topic 4100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004655/
https://www.ncbi.nlm.nih.gov/pubmed/32000390
http://dx.doi.org/10.1097/MD.0000000000018864
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