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Primary anorectal malignant melanoma: A case report
INTRODUCTION: Anorectal malignant melanoma (AMM) is a rare and aggressive malignance with poor prognosis, yet no consensus of treatment exists to date. Abdominoperineal resection surgery (APR) is the standard treatment of anorectal malignant melanoma, capable of controlling lymphatic spread and obta...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004677/ https://www.ncbi.nlm.nih.gov/pubmed/32000450 http://dx.doi.org/10.1097/MD.0000000000019028 |
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author | Xu, Xingdong Ge, Ting Wang, Gang |
author_facet | Xu, Xingdong Ge, Ting Wang, Gang |
author_sort | Xu, Xingdong |
collection | PubMed |
description | INTRODUCTION: Anorectal malignant melanoma (AMM) is a rare and aggressive malignance with poor prognosis, yet no consensus of treatment exists to date. Abdominoperineal resection surgery (APR) is the standard treatment of anorectal malignant melanoma, capable of controlling lymphatic spread and obtaining a large negative margin for local control but it can lead to complications. Wide local excision (WLE) allows for quicker recovery and has minimal impact on bowel function (i.e., bypassing the need for a stoma). PATIENT CONCERNS: A 66-year-old male patient presented with a 2-months history of painless rectal bleeding. DIAGNOSIS: The characteristic finding from colonoscopy and magnetic resonance imaging led to a diagnosis of colorectal cancer. Immunohistochemistry analyses confirmed malignant melanoma. The tumor was classified as: HMB-45(+), S-100(+), CD117(±), PCK(−), ki-67(+, 10%). INTERVENTIONS: The patient underwent abdominoperineal resection with no other adjuvant therapy. OUTCOMES: The patient is doing well at 24 month after the operation, with no signs of recurrence. CONCLUSION: AMM is a rare malignance, and is easy to misdiagnose. The therapy approach remains controversial. Every effort should be made to ensure prompt diagnosis and to define the optimally effective standard therapy approach. |
format | Online Article Text |
id | pubmed-7004677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-70046772020-02-18 Primary anorectal malignant melanoma: A case report Xu, Xingdong Ge, Ting Wang, Gang Medicine (Baltimore) 4500 INTRODUCTION: Anorectal malignant melanoma (AMM) is a rare and aggressive malignance with poor prognosis, yet no consensus of treatment exists to date. Abdominoperineal resection surgery (APR) is the standard treatment of anorectal malignant melanoma, capable of controlling lymphatic spread and obtaining a large negative margin for local control but it can lead to complications. Wide local excision (WLE) allows for quicker recovery and has minimal impact on bowel function (i.e., bypassing the need for a stoma). PATIENT CONCERNS: A 66-year-old male patient presented with a 2-months history of painless rectal bleeding. DIAGNOSIS: The characteristic finding from colonoscopy and magnetic resonance imaging led to a diagnosis of colorectal cancer. Immunohistochemistry analyses confirmed malignant melanoma. The tumor was classified as: HMB-45(+), S-100(+), CD117(±), PCK(−), ki-67(+, 10%). INTERVENTIONS: The patient underwent abdominoperineal resection with no other adjuvant therapy. OUTCOMES: The patient is doing well at 24 month after the operation, with no signs of recurrence. CONCLUSION: AMM is a rare malignance, and is easy to misdiagnose. The therapy approach remains controversial. Every effort should be made to ensure prompt diagnosis and to define the optimally effective standard therapy approach. Wolters Kluwer Health 2020-01-31 /pmc/articles/PMC7004677/ /pubmed/32000450 http://dx.doi.org/10.1097/MD.0000000000019028 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 4500 Xu, Xingdong Ge, Ting Wang, Gang Primary anorectal malignant melanoma: A case report |
title | Primary anorectal malignant melanoma: A case report |
title_full | Primary anorectal malignant melanoma: A case report |
title_fullStr | Primary anorectal malignant melanoma: A case report |
title_full_unstemmed | Primary anorectal malignant melanoma: A case report |
title_short | Primary anorectal malignant melanoma: A case report |
title_sort | primary anorectal malignant melanoma: a case report |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004677/ https://www.ncbi.nlm.nih.gov/pubmed/32000450 http://dx.doi.org/10.1097/MD.0000000000019028 |
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