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Primary lymphoma of the tibia in children: Two case reports

RATIONALE: Primary lymphoma of the bones (PLB) is a rare extranodal non-Hodgkin lymphoma (NHL) that is particularly rare in children. The clinical presentation and radiological features of PLB are often nonspecific, making clinical diagnosis challenging and misdiagnosis frequent. Here, we report 2 c...

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Autores principales: Suo, Haiqiang, Fu, Li, Wang, Zhiwei, Liang, Hanguang, Xu, Zhe, Feng, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004772/
https://www.ncbi.nlm.nih.gov/pubmed/31977874
http://dx.doi.org/10.1097/MD.0000000000018807
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author Suo, Haiqiang
Fu, Li
Wang, Zhiwei
Liang, Hanguang
Xu, Zhe
Feng, Wei
author_facet Suo, Haiqiang
Fu, Li
Wang, Zhiwei
Liang, Hanguang
Xu, Zhe
Feng, Wei
author_sort Suo, Haiqiang
collection PubMed
description RATIONALE: Primary lymphoma of the bones (PLB) is a rare extranodal non-Hodgkin lymphoma (NHL) that is particularly rare in children. The clinical presentation and radiological features of PLB are often nonspecific, making clinical diagnosis challenging and misdiagnosis frequent. Here, we report 2 children with PLB focusing on clinical presentation, differential diagnosis, and treatment outcomes. PATIENTS CONCERNS: A 9-year-old boy presented with left knee swelling and pain for 4 months after a fall. He was previously misdiagnosed with traumatic soft tissue injury. The second patient was an 11-year-old boy with a 6-month history of intermittent left knee pain. He was previously misdiagnosed with bone tuberculosis and chronic osteomyelitis. DIAGNOSES: A 9-year-old boy showed an abnormal signal of the left tibia metaphysis, diaphysis, and epiphysis, and tibia with periosteal reactions and surrounding soft tissue swelling. Tumor biopsy and immunohistochemistry confirmed a diagnosis of B-cell lymphoblastic lymphoma. An 11-year-old boy showed a permeative lesion in the metaphysis and diaphysis of the left proximal tibia. Tumor biopsy and immunohistochemistry confirmed the diagnosis of diffuse large B-cell lymphoma. INTERVENTIONS: Both patients were treated with 6 courses of NHL-Berlin-Frankfurt-Münster-95. OUTCOMES: Both patients are in complete clinical remission with a follow-up of 27 and 18months after treatment, respectively. LESSONS: PLB is a rare malignancy that is difficult to diagnose, particularly in children. Clinicians should increase the awareness of the disease and consider a differential diagnosis of bone lesions. Chemotherapy combined with radiotherapy is a favorable treatment for children with PLB. Early diagnosis and active treatment can improve patient prognosis.
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spelling pubmed-70047722020-02-19 Primary lymphoma of the tibia in children: Two case reports Suo, Haiqiang Fu, Li Wang, Zhiwei Liang, Hanguang Xu, Zhe Feng, Wei Medicine (Baltimore) 4800 RATIONALE: Primary lymphoma of the bones (PLB) is a rare extranodal non-Hodgkin lymphoma (NHL) that is particularly rare in children. The clinical presentation and radiological features of PLB are often nonspecific, making clinical diagnosis challenging and misdiagnosis frequent. Here, we report 2 children with PLB focusing on clinical presentation, differential diagnosis, and treatment outcomes. PATIENTS CONCERNS: A 9-year-old boy presented with left knee swelling and pain for 4 months after a fall. He was previously misdiagnosed with traumatic soft tissue injury. The second patient was an 11-year-old boy with a 6-month history of intermittent left knee pain. He was previously misdiagnosed with bone tuberculosis and chronic osteomyelitis. DIAGNOSES: A 9-year-old boy showed an abnormal signal of the left tibia metaphysis, diaphysis, and epiphysis, and tibia with periosteal reactions and surrounding soft tissue swelling. Tumor biopsy and immunohistochemistry confirmed a diagnosis of B-cell lymphoblastic lymphoma. An 11-year-old boy showed a permeative lesion in the metaphysis and diaphysis of the left proximal tibia. Tumor biopsy and immunohistochemistry confirmed the diagnosis of diffuse large B-cell lymphoma. INTERVENTIONS: Both patients were treated with 6 courses of NHL-Berlin-Frankfurt-Münster-95. OUTCOMES: Both patients are in complete clinical remission with a follow-up of 27 and 18months after treatment, respectively. LESSONS: PLB is a rare malignancy that is difficult to diagnose, particularly in children. Clinicians should increase the awareness of the disease and consider a differential diagnosis of bone lesions. Chemotherapy combined with radiotherapy is a favorable treatment for children with PLB. Early diagnosis and active treatment can improve patient prognosis. Wolters Kluwer Health 2020-01-24 /pmc/articles/PMC7004772/ /pubmed/31977874 http://dx.doi.org/10.1097/MD.0000000000018807 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4800
Suo, Haiqiang
Fu, Li
Wang, Zhiwei
Liang, Hanguang
Xu, Zhe
Feng, Wei
Primary lymphoma of the tibia in children: Two case reports
title Primary lymphoma of the tibia in children: Two case reports
title_full Primary lymphoma of the tibia in children: Two case reports
title_fullStr Primary lymphoma of the tibia in children: Two case reports
title_full_unstemmed Primary lymphoma of the tibia in children: Two case reports
title_short Primary lymphoma of the tibia in children: Two case reports
title_sort primary lymphoma of the tibia in children: two case reports
topic 4800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004772/
https://www.ncbi.nlm.nih.gov/pubmed/31977874
http://dx.doi.org/10.1097/MD.0000000000018807
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