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Role of MafB in macrophages
The transcription factor MafB regulates macrophage differentiation. However, studies on the phenotype of Mafb-deficient macrophages are still limited. Recently, it was shown that the specific expression of MafB permits macrophages to be distinguished from dendritic cells. In addition, MafB has been...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Association for Laboratory Animal Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004803/ https://www.ncbi.nlm.nih.gov/pubmed/31582643 http://dx.doi.org/10.1538/expanim.19-0076 |
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author | Hamada, Michito Tsunakawa, Yuki Jeon, Hyojung Yadav, Manoj Kumar Takahashi, Satoru |
author_facet | Hamada, Michito Tsunakawa, Yuki Jeon, Hyojung Yadav, Manoj Kumar Takahashi, Satoru |
author_sort | Hamada, Michito |
collection | PubMed |
description | The transcription factor MafB regulates macrophage differentiation. However, studies on the phenotype of Mafb-deficient macrophages are still limited. Recently, it was shown that the specific expression of MafB permits macrophages to be distinguished from dendritic cells. In addition, MafB has been reported to be involved in various diseases related to macrophages. Studies using macrophage-specific Mafb-deficient mice show that MafB is linked to atherosclerosis, autoimmunity, obesity, and ischemic stroke, all of which exhibit macrophage abnormality. Therefore, MafB is hypothesized to be indispensable for the regulation of macrophages to maintain systemic homeostasis and may serve as an innovative target for treating macrophage-related diseases. |
format | Online Article Text |
id | pubmed-7004803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-70048032020-02-11 Role of MafB in macrophages Hamada, Michito Tsunakawa, Yuki Jeon, Hyojung Yadav, Manoj Kumar Takahashi, Satoru Exp Anim Review The transcription factor MafB regulates macrophage differentiation. However, studies on the phenotype of Mafb-deficient macrophages are still limited. Recently, it was shown that the specific expression of MafB permits macrophages to be distinguished from dendritic cells. In addition, MafB has been reported to be involved in various diseases related to macrophages. Studies using macrophage-specific Mafb-deficient mice show that MafB is linked to atherosclerosis, autoimmunity, obesity, and ischemic stroke, all of which exhibit macrophage abnormality. Therefore, MafB is hypothesized to be indispensable for the regulation of macrophages to maintain systemic homeostasis and may serve as an innovative target for treating macrophage-related diseases. Japanese Association for Laboratory Animal Science 2019-10-01 2020 /pmc/articles/PMC7004803/ /pubmed/31582643 http://dx.doi.org/10.1538/expanim.19-0076 Text en ©2020 Japanese Association for Laboratory Animal Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Review Hamada, Michito Tsunakawa, Yuki Jeon, Hyojung Yadav, Manoj Kumar Takahashi, Satoru Role of MafB in macrophages |
title | Role of MafB in macrophages |
title_full | Role of MafB in macrophages |
title_fullStr | Role of MafB in macrophages |
title_full_unstemmed | Role of MafB in macrophages |
title_short | Role of MafB in macrophages |
title_sort | role of mafb in macrophages |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004803/ https://www.ncbi.nlm.nih.gov/pubmed/31582643 http://dx.doi.org/10.1538/expanim.19-0076 |
work_keys_str_mv | AT hamadamichito roleofmafbinmacrophages AT tsunakawayuki roleofmafbinmacrophages AT jeonhyojung roleofmafbinmacrophages AT yadavmanojkumar roleofmafbinmacrophages AT takahashisatoru roleofmafbinmacrophages |