Fast and accurate long-read assembly with wtdbg2

Existing long-read assemblers require thousands of CPU hours to assemble a human genome and are being outpaced by sequencing technologies in terms of both throughput and cost. We developed a long-read assembler wtdbg2 (https://github.com/ruanjue/wtdbg2) that is 2–17 times as fast as published tools...

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Detalles Bibliográficos
Autores principales: Ruan, Jue, Li, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004874/
https://www.ncbi.nlm.nih.gov/pubmed/31819265
http://dx.doi.org/10.1038/s41592-019-0669-3
Descripción
Sumario:Existing long-read assemblers require thousands of CPU hours to assemble a human genome and are being outpaced by sequencing technologies in terms of both throughput and cost. We developed a long-read assembler wtdbg2 (https://github.com/ruanjue/wtdbg2) that is 2–17 times as fast as published tools while achieving comparable contiguity and accuracy. It paves the way for population-scale long-read assembly in future.

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