Fast and accurate long-read assembly with wtdbg2

Existing long-read assemblers require thousands of CPU hours to assemble a human genome and are being outpaced by sequencing technologies in terms of both throughput and cost. We developed a long-read assembler wtdbg2 (https://github.com/ruanjue/wtdbg2) that is 2–17 times as fast as published tools...

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Detalles Bibliográficos
Autores principales: Ruan, Jue, Li, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004874/
https://www.ncbi.nlm.nih.gov/pubmed/31819265
http://dx.doi.org/10.1038/s41592-019-0669-3
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author Ruan, Jue
Li, Heng
author_facet Ruan, Jue
Li, Heng
author_sort Ruan, Jue
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description Existing long-read assemblers require thousands of CPU hours to assemble a human genome and are being outpaced by sequencing technologies in terms of both throughput and cost. We developed a long-read assembler wtdbg2 (https://github.com/ruanjue/wtdbg2) that is 2–17 times as fast as published tools while achieving comparable contiguity and accuracy. It paves the way for population-scale long-read assembly in future.
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spelling pubmed-70048742020-06-09 Fast and accurate long-read assembly with wtdbg2 Ruan, Jue Li, Heng Nat Methods Article Existing long-read assemblers require thousands of CPU hours to assemble a human genome and are being outpaced by sequencing technologies in terms of both throughput and cost. We developed a long-read assembler wtdbg2 (https://github.com/ruanjue/wtdbg2) that is 2–17 times as fast as published tools while achieving comparable contiguity and accuracy. It paves the way for population-scale long-read assembly in future. 2019-12-09 2020-02 /pmc/articles/PMC7004874/ /pubmed/31819265 http://dx.doi.org/10.1038/s41592-019-0669-3 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ruan, Jue
Li, Heng
Fast and accurate long-read assembly with wtdbg2
title Fast and accurate long-read assembly with wtdbg2
title_full Fast and accurate long-read assembly with wtdbg2
title_fullStr Fast and accurate long-read assembly with wtdbg2
title_full_unstemmed Fast and accurate long-read assembly with wtdbg2
title_short Fast and accurate long-read assembly with wtdbg2
title_sort fast and accurate long-read assembly with wtdbg2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004874/
https://www.ncbi.nlm.nih.gov/pubmed/31819265
http://dx.doi.org/10.1038/s41592-019-0669-3
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