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Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling

Amyloid beta peptides (Aβ) proteins play a key role in vascular pathology in Alzheimer’s Disease (AD) including impairment of the blood–brain barrier and aberrant angiogenesis. Although previous work has demonstrated a pro-angiogenic role of Aβ, the exact mechanisms by which amyloid precursor protei...

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Detalles Bibliográficos
Autores principales:	Durrant, Claire S., Ruscher, Karsten, Sheppard, Olivia, Coleman, Michael P., Özen, Ilknur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005019/ https://www.ncbi.nlm.nih.gov/pubmed/32029735 http://dx.doi.org/10.1038/s41419-020-2288-4

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