Cargando…

Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma

Lung squamous cell carcinomas (SCCs) are highly aggressive tumors, and there is currently no effective targeted therapy owing to the lack of specific mutation targets. Compared with lung adenocarcinoma (ADCs), lung SCCs reportedly utilized higher levels of glucose metabolism to meet the anabolic and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Wenzheng, Kuang, Yanbin, Wu, Jingjing, Wen, Donghua, Zhou, Aiping, Liao, Yueling, Song, Hongyong, Xu, Dongliang, Wang, Tong, Jing, Bo, Li, Kaimi, Hu, Min, Ling, Jing, Wang, Qi, Wu, Wenjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005048/ https://www.ncbi.nlm.nih.gov/pubmed/32083006 http://dx.doi.org/10.3389/fonc.2020.00052

Ejemplares similares

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
por: DeWaal, Dannielle, et al.
Publicado: (2018)

Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway
por: Kuang, Yanbin, et al.
Publicado: (2019)

Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
por: DeWaal, Dannielle, et al.
Publicado: (2018)

Deubiquitination and stabilization of programmed cell death ligand 1 by ubiquitin‐specific peptidase 9, X‐linked in oral squamous cell carcinoma
por: Jingjing, Wu, et al.
Publicado: (2018)

ALDH2 Repression Promotes Lung Tumor Progression via Accumulated Acetaldehyde and DNA Damage()
por: Li, Kaimi, et al.
Publicado: (2019)

PTGES/PGE(2) signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model
por: Wang, Tong, et al.
Publicado: (2020)

Potassium ions promote hexokinase-II dependent glycolysis
por: Bischof, Helmut, et al.
Publicado: (2021)

NEDD9 sustains hexokinase expression to promote glycolysis
por: Deneka, Alexander Y., et al.
Publicado: (2022)

Potassium ions promote hexokinase-II dependent glycolysis
por: Bischof, Helmut, et al.
Publicado: (2021)

MicroRNA-202 suppresses glycolysis of pancreatic cancer by targeting hexokinase 2
por: Wang, Shuang-Jia, et al.
Publicado: (2021)

NF-κB represses retinoic acid receptor–mediated GPRC5A transactivation in lung epithelial cells to promote neoplasia
por: Song, Hongyong, et al.
Publicado: (2023)

Repression of GPRC5A is associated with activated STAT3, which contributes to tumor progression of head and neck squamous cell carcinoma
por: Liu, Shuli, et al.
Publicado: (2017)

Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia
por: Chen, Guanhui, et al.
Publicado: (2018)

Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c‐myc/hexokinase 2 pathway
por: Yu, Qiang, et al.
Publicado: (2022)

Xanthohumol suppresses glioblastoma via modulation of Hexokinase 2 -mediated glycolysis
por: Yuan, Jian, et al.
Publicado: (2020)

Hexokinase 2-driven glycolysis in pericytes activates their contractility leading to tumor blood vessel abnormalities
por: Meng, Ya-Ming, et al.
Publicado: (2021)

Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis
por: Chen, Xin, et al.
Publicado: (2021)

By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice
por: Dai, Weiqi, et al.
Publicado: (2015)

STAT3 regulates glycolysis via targeting hexokinase 2 in hepatocellular carcinoma cells
por: Li, Man, et al.
Publicado: (2017)

Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma
por: Gershon, Timothy R, et al.
Publicado: (2013)

Tristetraprolin-mediated hexokinase 2 expression regulation contributes to glycolysis in cancer cells
por: Kim, Dong Jun, et al.
Publicado: (2019)

miR-125a suppresses viability and glycolysis and induces apoptosis by targeting Hexokinase 2 in laryngeal squamous cell carcinoma
por: Sun, Zhanwei, et al.
Publicado: (2017)

Lipopolysaccharide promotes metastasis via acceleration of glycolysis by the nuclear factor-κB/snail/hexokinase3 signaling axis in colorectal cancer
por: Wu, Xuesong, et al.
Publicado: (2021)

High Vimentin Expression Associated with Lymph Node Metastasis and Predicated a Poor Prognosis in Oral Squamous Cell Carcinoma
por: Liu, Shuli, et al.
Publicado: (2016)

Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin
por: Šimčíková, Daniela, et al.
Publicado: (2021)

Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2
por: Xu, Dong, et al.
Publicado: (2017)

Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells
por: Caillot, M., et al.
Publicado: (2020)

Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis
por: Liu, Wenbin, et al.
Publicado: (2019)

SALL4 promotes gastric cancer progression via hexokinase II mediated glycolysis
por: Shao, Meng, et al.
Publicado: (2020)

Hexokinase 2-mediated glycolysis supports inflammatory responses to Porphyromonas gingivalis in gingival fibroblasts
por: Su, Wenqi, et al.
Publicado: (2023)

Hexokinase 2 Is a Pivot for Lovastatin-induced Glycolysis-to-Autophagy Reprogramming in Triple-Negative Breast Cancer Cells
por: Xue, Lian, et al.
Publicado: (2022)

Let-7b-5p inhibits breast cancer cell growth and metastasis via repression of hexokinase 2-mediated aerobic glycolysis
por: Li, Ling, et al.
Publicado: (2023)

Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway
por: Wu, Hongyan, et al.
Publicado: (2019)

Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells
por: Liu, Yulin, et al.
Publicado: (2017)

Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis
por: Li, Wei, et al.
Publicado: (2017)

High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss.
por: Oudard, S., et al.
Publicado: (1996)

Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells()
por: Mukherjee, Abir, et al.
Publicado: (2015)

Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2
por: Ban, Dujing, et al.
Publicado: (2019)

Histone H2AX promotes metastatic progression by preserving glycolysis via hexokinase-2
por: Liu, Yue, et al.
Publicado: (2022)

BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells
por: An, Ming-Xin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1i2ceka67uk3sr2tk3ck739nn5