Molecular Dynamics Simulations of a Chimeric Androgen Receptor Protein (SPARKI) Confirm the Importance of the Dimerization Domain on DNA Binding Specificity

The DNA binding domains of Androgen/Glucocorticoid receptors (AR/GR), members of class I steroid receptors, bind as a homo-dimer to a cis-regulatory element. These response elements are arranged as inverted repeat (IR) of hexamer “AGAACA”, separated with a 3 base pairs spacer. DNA binding domains of...

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Detalles Bibliográficos
Autores principales: Bagherpoor Helabad, Mahdi, Volkenandt, Senta, Imhof, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005049/
https://www.ncbi.nlm.nih.gov/pubmed/32083093
http://dx.doi.org/10.3389/fmolb.2020.00004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005049/
https://www.ncbi.nlm.nih.gov/pubmed/32083093
http://dx.doi.org/10.3389/fmolb.2020.00004

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