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Structural Variants May Be a Source of Missing Heritability in sALS
The underlying genetic and molecular mechanisms that drive amyotrophic lateral sclerosis (ALS) remain poorly understood. Structural variants within the genome can play a significant role in neurodegenerative disease risk, such as the repeat expansion in C9orf72 and the tri-nucleotide repeat in ATXN2...
Autores principales: | Theunissen, Frances, Flynn, Loren L., Anderton, Ryan S., Mastaglia, Frank, Pytte, Julia, Jiang, Leanne, Hodgetts, Stuart, Burns, Daniel K., Saunders, Ann, Fletcher, Sue, Wilton, Steve D., Akkari, Patrick Anthony |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005198/ https://www.ncbi.nlm.nih.gov/pubmed/32082115 http://dx.doi.org/10.3389/fnins.2020.00047 |
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