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Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with very poor prognosis and few advances in its treatment. Recently, fast-growing cancer immunotherapy provides a glimmer of hope for GBM treatment. Adoptive cell therapy (ACT) aims at infusing immune cells with direct a...

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Autores principales: Wang, Jingyu, Shen, Fang, Yao, Ying, Wang, Lin-lin, Zhu, Yongjian, Hu, Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005203/
https://www.ncbi.nlm.nih.gov/pubmed/32083009
http://dx.doi.org/10.3389/fonc.2020.00059
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author Wang, Jingyu
Shen, Fang
Yao, Ying
Wang, Lin-lin
Zhu, Yongjian
Hu, Jue
author_facet Wang, Jingyu
Shen, Fang
Yao, Ying
Wang, Lin-lin
Zhu, Yongjian
Hu, Jue
author_sort Wang, Jingyu
collection PubMed
description Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with very poor prognosis and few advances in its treatment. Recently, fast-growing cancer immunotherapy provides a glimmer of hope for GBM treatment. Adoptive cell therapy (ACT) aims at infusing immune cells with direct anti-tumor activity, including tumor-infiltrating lymphocyte (TIL) transfer and genetically engineered T cells transfer. For example, complete regressions in patients with melanoma and refractory lymphoma have been shown by using naturally tumor-reactive T cells and genetically engineered T cells expressing the chimeric anti-CD19 receptor, respectively. Recently, the administration of ACT showed therapeutic potentials for GBM treatment as well. In this review, we summarize the success of ACT in the treatment of cancer and provide approaches to overcome some challenges of ACT to allow its adoption for GBM treatment.
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spelling pubmed-70052032020-02-20 Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma Wang, Jingyu Shen, Fang Yao, Ying Wang, Lin-lin Zhu, Yongjian Hu, Jue Front Oncol Oncology Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with very poor prognosis and few advances in its treatment. Recently, fast-growing cancer immunotherapy provides a glimmer of hope for GBM treatment. Adoptive cell therapy (ACT) aims at infusing immune cells with direct anti-tumor activity, including tumor-infiltrating lymphocyte (TIL) transfer and genetically engineered T cells transfer. For example, complete regressions in patients with melanoma and refractory lymphoma have been shown by using naturally tumor-reactive T cells and genetically engineered T cells expressing the chimeric anti-CD19 receptor, respectively. Recently, the administration of ACT showed therapeutic potentials for GBM treatment as well. In this review, we summarize the success of ACT in the treatment of cancer and provide approaches to overcome some challenges of ACT to allow its adoption for GBM treatment. Frontiers Media S.A. 2020-01-31 /pmc/articles/PMC7005203/ /pubmed/32083009 http://dx.doi.org/10.3389/fonc.2020.00059 Text en Copyright © 2020 Wang, Shen, Yao, Wang, Zhu and Hu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Jingyu
Shen, Fang
Yao, Ying
Wang, Lin-lin
Zhu, Yongjian
Hu, Jue
Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma
title Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma
title_full Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma
title_fullStr Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma
title_full_unstemmed Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma
title_short Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma
title_sort adoptive cell therapy: a novel and potential immunotherapy for glioblastoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005203/
https://www.ncbi.nlm.nih.gov/pubmed/32083009
http://dx.doi.org/10.3389/fonc.2020.00059
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