Cargando…
Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with very poor prognosis and few advances in its treatment. Recently, fast-growing cancer immunotherapy provides a glimmer of hope for GBM treatment. Adoptive cell therapy (ACT) aims at infusing immune cells with direct a...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005203/ https://www.ncbi.nlm.nih.gov/pubmed/32083009 http://dx.doi.org/10.3389/fonc.2020.00059 |
_version_ | 1783494885253316608 |
---|---|
author | Wang, Jingyu Shen, Fang Yao, Ying Wang, Lin-lin Zhu, Yongjian Hu, Jue |
author_facet | Wang, Jingyu Shen, Fang Yao, Ying Wang, Lin-lin Zhu, Yongjian Hu, Jue |
author_sort | Wang, Jingyu |
collection | PubMed |
description | Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with very poor prognosis and few advances in its treatment. Recently, fast-growing cancer immunotherapy provides a glimmer of hope for GBM treatment. Adoptive cell therapy (ACT) aims at infusing immune cells with direct anti-tumor activity, including tumor-infiltrating lymphocyte (TIL) transfer and genetically engineered T cells transfer. For example, complete regressions in patients with melanoma and refractory lymphoma have been shown by using naturally tumor-reactive T cells and genetically engineered T cells expressing the chimeric anti-CD19 receptor, respectively. Recently, the administration of ACT showed therapeutic potentials for GBM treatment as well. In this review, we summarize the success of ACT in the treatment of cancer and provide approaches to overcome some challenges of ACT to allow its adoption for GBM treatment. |
format | Online Article Text |
id | pubmed-7005203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70052032020-02-20 Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma Wang, Jingyu Shen, Fang Yao, Ying Wang, Lin-lin Zhu, Yongjian Hu, Jue Front Oncol Oncology Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with very poor prognosis and few advances in its treatment. Recently, fast-growing cancer immunotherapy provides a glimmer of hope for GBM treatment. Adoptive cell therapy (ACT) aims at infusing immune cells with direct anti-tumor activity, including tumor-infiltrating lymphocyte (TIL) transfer and genetically engineered T cells transfer. For example, complete regressions in patients with melanoma and refractory lymphoma have been shown by using naturally tumor-reactive T cells and genetically engineered T cells expressing the chimeric anti-CD19 receptor, respectively. Recently, the administration of ACT showed therapeutic potentials for GBM treatment as well. In this review, we summarize the success of ACT in the treatment of cancer and provide approaches to overcome some challenges of ACT to allow its adoption for GBM treatment. Frontiers Media S.A. 2020-01-31 /pmc/articles/PMC7005203/ /pubmed/32083009 http://dx.doi.org/10.3389/fonc.2020.00059 Text en Copyright © 2020 Wang, Shen, Yao, Wang, Zhu and Hu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wang, Jingyu Shen, Fang Yao, Ying Wang, Lin-lin Zhu, Yongjian Hu, Jue Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma |
title | Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma |
title_full | Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma |
title_fullStr | Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma |
title_full_unstemmed | Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma |
title_short | Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma |
title_sort | adoptive cell therapy: a novel and potential immunotherapy for glioblastoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005203/ https://www.ncbi.nlm.nih.gov/pubmed/32083009 http://dx.doi.org/10.3389/fonc.2020.00059 |
work_keys_str_mv | AT wangjingyu adoptivecelltherapyanovelandpotentialimmunotherapyforglioblastoma AT shenfang adoptivecelltherapyanovelandpotentialimmunotherapyforglioblastoma AT yaoying adoptivecelltherapyanovelandpotentialimmunotherapyforglioblastoma AT wanglinlin adoptivecelltherapyanovelandpotentialimmunotherapyforglioblastoma AT zhuyongjian adoptivecelltherapyanovelandpotentialimmunotherapyforglioblastoma AT hujue adoptivecelltherapyanovelandpotentialimmunotherapyforglioblastoma |