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N(6)-Methyladenosine: A Potential Breakthrough for Human Cancer
Among more than 100 types of identified RNA modification, N(6)-methyladenosine (m(6)A) modification is the predominant mRNA modification, which regulates RNA splicing, translocation, stability, and translation. m(6)A modification plays critical roles in the growth, differentiation, and metabolism of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005339/ https://www.ncbi.nlm.nih.gov/pubmed/31958696 http://dx.doi.org/10.1016/j.omtn.2019.12.013 |
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author | Liu, Lina Wang, Yuwei Wu, Jie Liu, Jingwen Qin, Zongchang Fan, Hong |
author_facet | Liu, Lina Wang, Yuwei Wu, Jie Liu, Jingwen Qin, Zongchang Fan, Hong |
author_sort | Liu, Lina |
collection | PubMed |
description | Among more than 100 types of identified RNA modification, N(6)-methyladenosine (m(6)A) modification is the predominant mRNA modification, which regulates RNA splicing, translocation, stability, and translation. m(6)A modification plays critical roles in the growth, differentiation, and metabolism of cells. As a dynamic and reversible modification, m(6)A is catalyzed by “writers” (RNA methyltransferases), removed by “erasers” (demethylases), and interacts with “readers” (m(6)A-binding proteins). With more advanced technology applied to research, the molecular mechanisms of RNA methyltransferase, demethylase, and m(6)A-binding protein have been revealed. An increasing number of studies have implicated the correlation between m(6)A modification and human cancers. In this review, we summarize that the occurrence and development of various human cancers are associated with aberrant m(6)A modification. We also discuss the progress in research related to m(6)A modification, providing novel therapeutic insight and potential breakthrough in anticancer therapy. |
format | Online Article Text |
id | pubmed-7005339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Society of Gene & Cell Therapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-70053392020-02-13 N(6)-Methyladenosine: A Potential Breakthrough for Human Cancer Liu, Lina Wang, Yuwei Wu, Jie Liu, Jingwen Qin, Zongchang Fan, Hong Mol Ther Nucleic Acids Article Among more than 100 types of identified RNA modification, N(6)-methyladenosine (m(6)A) modification is the predominant mRNA modification, which regulates RNA splicing, translocation, stability, and translation. m(6)A modification plays critical roles in the growth, differentiation, and metabolism of cells. As a dynamic and reversible modification, m(6)A is catalyzed by “writers” (RNA methyltransferases), removed by “erasers” (demethylases), and interacts with “readers” (m(6)A-binding proteins). With more advanced technology applied to research, the molecular mechanisms of RNA methyltransferase, demethylase, and m(6)A-binding protein have been revealed. An increasing number of studies have implicated the correlation between m(6)A modification and human cancers. In this review, we summarize that the occurrence and development of various human cancers are associated with aberrant m(6)A modification. We also discuss the progress in research related to m(6)A modification, providing novel therapeutic insight and potential breakthrough in anticancer therapy. American Society of Gene & Cell Therapy 2019-12-20 /pmc/articles/PMC7005339/ /pubmed/31958696 http://dx.doi.org/10.1016/j.omtn.2019.12.013 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Liu, Lina Wang, Yuwei Wu, Jie Liu, Jingwen Qin, Zongchang Fan, Hong N(6)-Methyladenosine: A Potential Breakthrough for Human Cancer |
title | N(6)-Methyladenosine: A Potential Breakthrough for Human Cancer |
title_full | N(6)-Methyladenosine: A Potential Breakthrough for Human Cancer |
title_fullStr | N(6)-Methyladenosine: A Potential Breakthrough for Human Cancer |
title_full_unstemmed | N(6)-Methyladenosine: A Potential Breakthrough for Human Cancer |
title_short | N(6)-Methyladenosine: A Potential Breakthrough for Human Cancer |
title_sort | n(6)-methyladenosine: a potential breakthrough for human cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005339/ https://www.ncbi.nlm.nih.gov/pubmed/31958696 http://dx.doi.org/10.1016/j.omtn.2019.12.013 |
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