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The Glu102 mutation disrupts higher-order oligomerization of the sigma 1 receptor

The sigma 1 receptor (σ1R) is a unique endoplasmic reticulum membrane protein. Its ligands have been shown to possess therapeutic potential for neurological and substance use disorders among others. The E102Q mutation of σ1R has been found to elicit familial cases of amyotrophic lateral sclerosis (A...

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Detalles Bibliográficos
Autores principales:	Abramyan, Ara M., Yano, Hideaki, Xu, Min, Liu, Leanne, Naing, Sett, Fant, Andrew D., Shi, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005341/ https://www.ncbi.nlm.nih.gov/pubmed/32055286 http://dx.doi.org/10.1016/j.csbj.2019.12.012

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