Inhibition of USP14 Deubiquitinating Activity as a Potential Therapy for Tumors with p53 Deficiency

Functional elimination of p53 is a common feature of a large percentage of human malignancies. Here, we report the development of a pharmacological strategy aimed at restoring p53 function and its use for targeted therapy in p53-deficient mice. Specific inhibition of deubiquitinases ubiquitin-specif...

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Detalles Bibliográficos
Autores principales: Ma, Yu-Shui, Wang, Xiao-Feng, Zhang, Yun-Jie, Luo, Pei, Long, Hui-Deng, Li, Liu, Yang, Hui-Qiong, Xie, Ru-Ting, Jia, Cheng-You, Lu, Gai-Xia, Chang, Zheng-Yan, Zhang, Jia-Jia, Xue, Shao-Bo, Lv, Zhong-Wei, Yu, Fei, Xia, Qing, Fu, Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005481/
https://www.ncbi.nlm.nih.gov/pubmed/32055678
http://dx.doi.org/10.1016/j.omto.2019.12.013

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