Ultrasound-Responsive Materials for Drug/Gene Delivery

Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of...

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Autores principales: Cai, Xiaowen, Jiang, Yuan, Lin, Mei, Zhang, Jiyong, Guo, Huanhuan, Yang, Fanwen, Leung, Wingnang, Xu, Chuanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005489/
https://www.ncbi.nlm.nih.gov/pubmed/32082157
http://dx.doi.org/10.3389/fphar.2019.01650
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author Cai, Xiaowen
Jiang, Yuan
Lin, Mei
Zhang, Jiyong
Guo, Huanhuan
Yang, Fanwen
Leung, Wingnang
Xu, Chuanshan
author_facet Cai, Xiaowen
Jiang, Yuan
Lin, Mei
Zhang, Jiyong
Guo, Huanhuan
Yang, Fanwen
Leung, Wingnang
Xu, Chuanshan
author_sort Cai, Xiaowen
collection PubMed
description Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of drugs/genes and attracts increasing attention. Microbubbles are the most well-known ultrasound-responsive delivery materials. Recently, nanobubbles, droplets, micelles, and nanoliposomes have been developed as novel carriers in this field. Herein, we review advances of novel ultrasound-responsive materials (nanobubbles, droplets, micelles and nanoliposomes) and discuss the challenges of ultrasound-responsive materials in delivery systems to boost the development of ultrasound-responsive materials as delivery carriers.
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spelling pubmed-70054892020-02-20 Ultrasound-Responsive Materials for Drug/Gene Delivery Cai, Xiaowen Jiang, Yuan Lin, Mei Zhang, Jiyong Guo, Huanhuan Yang, Fanwen Leung, Wingnang Xu, Chuanshan Front Pharmacol Pharmacology Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of drugs/genes and attracts increasing attention. Microbubbles are the most well-known ultrasound-responsive delivery materials. Recently, nanobubbles, droplets, micelles, and nanoliposomes have been developed as novel carriers in this field. Herein, we review advances of novel ultrasound-responsive materials (nanobubbles, droplets, micelles and nanoliposomes) and discuss the challenges of ultrasound-responsive materials in delivery systems to boost the development of ultrasound-responsive materials as delivery carriers. Frontiers Media S.A. 2020-01-31 /pmc/articles/PMC7005489/ /pubmed/32082157 http://dx.doi.org/10.3389/fphar.2019.01650 Text en Copyright © 2020 Cai, Jiang, Lin, Zhang, Guo, Yang, Leung and Xu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Cai, Xiaowen
Jiang, Yuan
Lin, Mei
Zhang, Jiyong
Guo, Huanhuan
Yang, Fanwen
Leung, Wingnang
Xu, Chuanshan
Ultrasound-Responsive Materials for Drug/Gene Delivery
title Ultrasound-Responsive Materials for Drug/Gene Delivery
title_full Ultrasound-Responsive Materials for Drug/Gene Delivery
title_fullStr Ultrasound-Responsive Materials for Drug/Gene Delivery
title_full_unstemmed Ultrasound-Responsive Materials for Drug/Gene Delivery
title_short Ultrasound-Responsive Materials for Drug/Gene Delivery
title_sort ultrasound-responsive materials for drug/gene delivery
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005489/
https://www.ncbi.nlm.nih.gov/pubmed/32082157
http://dx.doi.org/10.3389/fphar.2019.01650
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AT guohuanhuan ultrasoundresponsivematerialsfordruggenedelivery
AT yangfanwen ultrasoundresponsivematerialsfordruggenedelivery
AT leungwingnang ultrasoundresponsivematerialsfordruggenedelivery
AT xuchuanshan ultrasoundresponsivematerialsfordruggenedelivery

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