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Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
The presented data article reports protein expression profiles during a time course of limb regeneration in the highly regenerative neotenic and regeneration-deficient metamorphic axolotl (Ambystoma mexicanum). A protein database was first generated from transcriptome data, which was used concomitan...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005509/ https://www.ncbi.nlm.nih.gov/pubmed/32055664 http://dx.doi.org/10.1016/j.dib.2020.105179 |
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author | Demircan, Turan Sibai, Mustafa Altuntaş, Ebru |
author_facet | Demircan, Turan Sibai, Mustafa Altuntaş, Ebru |
author_sort | Demircan, Turan |
collection | PubMed |
description | The presented data article reports protein expression profiles during a time course of limb regeneration in the highly regenerative neotenic and regeneration-deficient metamorphic axolotl (Ambystoma mexicanum). A protein database was first generated from transcriptome data, which was used concomitantly with nanoLC-MS/MS to identify and assess significant changes of protein levels among 0, 1, 4, and 7 days post-amputation (dpa) in both animal stages, yielding a total of 714 significant differentially expressed proteins. Gene ontology categories of these identified proteins were examined in terms of biological processes, molecular function and cellular components. Innate clustering patterns of the samples were investigated using hierarchical clustering and were visualized on a heatmap. The data reported here constitutes an extension of “Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl” article Sibai et al., 2019 [1]. The associated mass spectrometry raw data have been deposited in the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) with the dataset identifier PXD014806. |
format | Online Article Text |
id | pubmed-7005509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-70055092020-02-13 Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages Demircan, Turan Sibai, Mustafa Altuntaş, Ebru Data Brief Proteomics The presented data article reports protein expression profiles during a time course of limb regeneration in the highly regenerative neotenic and regeneration-deficient metamorphic axolotl (Ambystoma mexicanum). A protein database was first generated from transcriptome data, which was used concomitantly with nanoLC-MS/MS to identify and assess significant changes of protein levels among 0, 1, 4, and 7 days post-amputation (dpa) in both animal stages, yielding a total of 714 significant differentially expressed proteins. Gene ontology categories of these identified proteins were examined in terms of biological processes, molecular function and cellular components. Innate clustering patterns of the samples were investigated using hierarchical clustering and were visualized on a heatmap. The data reported here constitutes an extension of “Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl” article Sibai et al., 2019 [1]. The associated mass spectrometry raw data have been deposited in the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) with the dataset identifier PXD014806. Elsevier 2020-01-28 /pmc/articles/PMC7005509/ /pubmed/32055664 http://dx.doi.org/10.1016/j.dib.2020.105179 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Proteomics Demircan, Turan Sibai, Mustafa Altuntaş, Ebru Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages |
title | Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages |
title_full | Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages |
title_fullStr | Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages |
title_full_unstemmed | Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages |
title_short | Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages |
title_sort | proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages |
topic | Proteomics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005509/ https://www.ncbi.nlm.nih.gov/pubmed/32055664 http://dx.doi.org/10.1016/j.dib.2020.105179 |
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