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Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages

The presented data article reports protein expression profiles during a time course of limb regeneration in the highly regenerative neotenic and regeneration-deficient metamorphic axolotl (Ambystoma mexicanum). A protein database was first generated from transcriptome data, which was used concomitan...

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Detalles Bibliográficos
Autores principales: Demircan, Turan, Sibai, Mustafa, Altuntaş, Ebru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005509/
https://www.ncbi.nlm.nih.gov/pubmed/32055664
http://dx.doi.org/10.1016/j.dib.2020.105179
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author Demircan, Turan
Sibai, Mustafa
Altuntaş, Ebru
author_facet Demircan, Turan
Sibai, Mustafa
Altuntaş, Ebru
author_sort Demircan, Turan
collection PubMed
description The presented data article reports protein expression profiles during a time course of limb regeneration in the highly regenerative neotenic and regeneration-deficient metamorphic axolotl (Ambystoma mexicanum). A protein database was first generated from transcriptome data, which was used concomitantly with nanoLC-MS/MS to identify and assess significant changes of protein levels among 0, 1, 4, and 7 days post-amputation (dpa) in both animal stages, yielding a total of 714 significant differentially expressed proteins. Gene ontology categories of these identified proteins were examined in terms of biological processes, molecular function and cellular components. Innate clustering patterns of the samples were investigated using hierarchical clustering and were visualized on a heatmap. The data reported here constitutes an extension of “Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl” article Sibai et al., 2019 [1]. The associated mass spectrometry raw data have been deposited in the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) with the dataset identifier PXD014806.
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spelling pubmed-70055092020-02-13 Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages Demircan, Turan Sibai, Mustafa Altuntaş, Ebru Data Brief Proteomics The presented data article reports protein expression profiles during a time course of limb regeneration in the highly regenerative neotenic and regeneration-deficient metamorphic axolotl (Ambystoma mexicanum). A protein database was first generated from transcriptome data, which was used concomitantly with nanoLC-MS/MS to identify and assess significant changes of protein levels among 0, 1, 4, and 7 days post-amputation (dpa) in both animal stages, yielding a total of 714 significant differentially expressed proteins. Gene ontology categories of these identified proteins were examined in terms of biological processes, molecular function and cellular components. Innate clustering patterns of the samples were investigated using hierarchical clustering and were visualized on a heatmap. The data reported here constitutes an extension of “Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl” article Sibai et al., 2019 [1]. The associated mass spectrometry raw data have been deposited in the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) with the dataset identifier PXD014806. Elsevier 2020-01-28 /pmc/articles/PMC7005509/ /pubmed/32055664 http://dx.doi.org/10.1016/j.dib.2020.105179 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Proteomics
Demircan, Turan
Sibai, Mustafa
Altuntaş, Ebru
Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
title Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
title_full Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
title_fullStr Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
title_full_unstemmed Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
title_short Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
title_sort proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
topic Proteomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005509/
https://www.ncbi.nlm.nih.gov/pubmed/32055664
http://dx.doi.org/10.1016/j.dib.2020.105179
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