Dynamic (13)C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

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Cellular metabolism is dynamic, but quantifying non-steady metabolic fluxes by stable isotope tracers presents unique computational challenges. Here, we developed an efficient (13)C-tracer dynamic metabolic flux analysis (13C-DMFA) framework for modeling central carbon fluxes that vary over time. We...

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Detalles Bibliográficos
Autores principales: Quek, Lake-Ee, Krycer, James R., Ohno, Satoshi, Yugi, Katsuyuki, Fazakerley, Daniel J., Scalzo, Richard, Elkington, Sarah D., Dai, Ziwei, Hirayama, Akiyoshi, Ikeda, Satsuki, Shoji, Futaba, Suzuki, Kumi, Locasale, Jason W., Soga, Tomoyoshi, James, David E., Kuroda, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005519/
https://www.ncbi.nlm.nih.gov/pubmed/32058966
http://dx.doi.org/10.1016/j.isci.2020.100855
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