“Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP

Pathological angiogenesis contributes to tumour progression as well as to chronic inflammatory diseases. In this issue of EMBO Molecular Medicine, Esteban and co‐workers identify endothelial cell MT1‐MMP as a key regulator of intussusceptive angiogenesis (IA) in inflammatory colitis. Thrombospondin...

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Detalles Bibliográficos
Autores principales: D'Amico, Gabriela, Muñoz‐Félix, José M, Pedrosa, Ana Rita, Hodivala‐Dilke, Kairbaan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005529/
https://www.ncbi.nlm.nih.gov/pubmed/31858727
http://dx.doi.org/10.15252/emmm.201911663
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author D'Amico, Gabriela
Muñoz‐Félix, José M
Pedrosa, Ana Rita
Hodivala‐Dilke, Kairbaan M
author_facet D'Amico, Gabriela
Muñoz‐Félix, José M
Pedrosa, Ana Rita
Hodivala‐Dilke, Kairbaan M
author_sort D'Amico, Gabriela
collection PubMed
description Pathological angiogenesis contributes to tumour progression as well as to chronic inflammatory diseases. In this issue of EMBO Molecular Medicine, Esteban and co‐workers identify endothelial cell MT1‐MMP as a key regulator of intussusceptive angiogenesis (IA) in inflammatory colitis. Thrombospondin 1 (TSP1) cleavage by MT1‐MMP results in the binding of the c‐terminal fragment of TSP1 to αvβ3 integrin, which induces nitric oxide (NO) production, vasodilation and further initiation of IA. This novel control mechanism of inflammatory IA points towards promising new therapeutic targets for inflammatory bowel disease.
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spelling pubmed-70055292020-02-13 “Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP D'Amico, Gabriela Muñoz‐Félix, José M Pedrosa, Ana Rita Hodivala‐Dilke, Kairbaan M EMBO Mol Med News & Views Pathological angiogenesis contributes to tumour progression as well as to chronic inflammatory diseases. In this issue of EMBO Molecular Medicine, Esteban and co‐workers identify endothelial cell MT1‐MMP as a key regulator of intussusceptive angiogenesis (IA) in inflammatory colitis. Thrombospondin 1 (TSP1) cleavage by MT1‐MMP results in the binding of the c‐terminal fragment of TSP1 to αvβ3 integrin, which induces nitric oxide (NO) production, vasodilation and further initiation of IA. This novel control mechanism of inflammatory IA points towards promising new therapeutic targets for inflammatory bowel disease. John Wiley and Sons Inc. 2019-12-20 2020-02-07 /pmc/articles/PMC7005529/ /pubmed/31858727 http://dx.doi.org/10.15252/emmm.201911663 Text en © 2019 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
D'Amico, Gabriela
Muñoz‐Félix, José M
Pedrosa, Ana Rita
Hodivala‐Dilke, Kairbaan M
“Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP
title “Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP
title_full “Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP
title_fullStr “Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP
title_full_unstemmed “Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP
title_short “Splitting the matrix”: intussusceptive angiogenesis meets MT1‐MMP
title_sort “splitting the matrix”: intussusceptive angiogenesis meets mt1‐mmp
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005529/
https://www.ncbi.nlm.nih.gov/pubmed/31858727
http://dx.doi.org/10.15252/emmm.201911663
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