Elevated international normalized ratio (INR) and new diagnosis of hepatitis C associated with severe intrahepatic cholestasis of pregnancy (ICP): A case report

BACKGROUND: Severe intrahepatic cholestasis of pregnancy (ICP), defined as a serum bile acid (SBA) level > 100 μmol/l, remains poorly understood in its mechanism and implications. CASE: A patient with a missed diagnosis of mild ICP went on to develop clinical jaundice and liver function abnormali...

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Detalles Bibliográficos
Autores principales: Birchall, Courtney, Prentice, Danielle, Pauli, Jaimey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005562/
https://www.ncbi.nlm.nih.gov/pubmed/32055455
http://dx.doi.org/10.1016/j.crwh.2020.e00178
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author Birchall, Courtney
Prentice, Danielle
Pauli, Jaimey
author_facet Birchall, Courtney
Prentice, Danielle
Pauli, Jaimey
author_sort Birchall, Courtney
collection PubMed
description BACKGROUND: Severe intrahepatic cholestasis of pregnancy (ICP), defined as a serum bile acid (SBA) level > 100 μmol/l, remains poorly understood in its mechanism and implications. CASE: A patient with a missed diagnosis of mild ICP went on to develop clinical jaundice and liver function abnormalities in the setting of newly diagnosed hepatitis C and severe ICP on repeat SBA testing. CONCLUSION: This case highlights and adds to the growing body of evidence supporting the need for universal screening for hepatitis C in ICP patients and the potential role for repeat SBA testing, which would be a notable change from the traditional care of these individuals.
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spelling pubmed-70055622020-02-13 Elevated international normalized ratio (INR) and new diagnosis of hepatitis C associated with severe intrahepatic cholestasis of pregnancy (ICP): A case report Birchall, Courtney Prentice, Danielle Pauli, Jaimey Case Rep Womens Health Article BACKGROUND: Severe intrahepatic cholestasis of pregnancy (ICP), defined as a serum bile acid (SBA) level > 100 μmol/l, remains poorly understood in its mechanism and implications. CASE: A patient with a missed diagnosis of mild ICP went on to develop clinical jaundice and liver function abnormalities in the setting of newly diagnosed hepatitis C and severe ICP on repeat SBA testing. CONCLUSION: This case highlights and adds to the growing body of evidence supporting the need for universal screening for hepatitis C in ICP patients and the potential role for repeat SBA testing, which would be a notable change from the traditional care of these individuals. Elsevier 2020-01-30 /pmc/articles/PMC7005562/ /pubmed/32055455 http://dx.doi.org/10.1016/j.crwh.2020.e00178 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Birchall, Courtney
Prentice, Danielle
Pauli, Jaimey
Elevated international normalized ratio (INR) and new diagnosis of hepatitis C associated with severe intrahepatic cholestasis of pregnancy (ICP): A case report
title Elevated international normalized ratio (INR) and new diagnosis of hepatitis C associated with severe intrahepatic cholestasis of pregnancy (ICP): A case report
title_full Elevated international normalized ratio (INR) and new diagnosis of hepatitis C associated with severe intrahepatic cholestasis of pregnancy (ICP): A case report
title_fullStr Elevated international normalized ratio (INR) and new diagnosis of hepatitis C associated with severe intrahepatic cholestasis of pregnancy (ICP): A case report
title_full_unstemmed Elevated international normalized ratio (INR) and new diagnosis of hepatitis C associated with severe intrahepatic cholestasis of pregnancy (ICP): A case report
title_short Elevated international normalized ratio (INR) and new diagnosis of hepatitis C associated with severe intrahepatic cholestasis of pregnancy (ICP): A case report
title_sort elevated international normalized ratio (inr) and new diagnosis of hepatitis c associated with severe intrahepatic cholestasis of pregnancy (icp): a case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005562/
https://www.ncbi.nlm.nih.gov/pubmed/32055455
http://dx.doi.org/10.1016/j.crwh.2020.e00178
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