Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis

BACKGROUND & AIMS: A DNA methylation (DNAm) signature derived from 353 CpG sites (the Horvath clock) has been proposed as an epigenetic measure of chronological and biological age. This epigenetic signature is accelerated in diverse tissue types in various disorders, including non-alcoholic stea...

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Detalles Bibliográficos
Autores principales: Trauner, Michael, Gindin, Yevgeniy, Jiang, Zhaoshi, Chung, Chuhan, Subramanian, G. Mani, Myers, Robert P., Gulamhusein, Aliya, Kowdley, Kris V., Levy, Cynthia, Goodman, Zachary, Manns, Michael P., Muir, Andrew J., Bowlus, Christopher L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005566/
https://www.ncbi.nlm.nih.gov/pubmed/32039401
http://dx.doi.org/10.1016/j.jhepr.2019.11.004

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