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Twente Photoacoustic Mammoscope 2: system overview and three-dimensional vascular network images in healthy breasts
We present the Twente Photoacoustic Mammoscope 2, a photoacoustic breast imaging system employing a tomographic configuration. It images one breast pendant inside an imaging tank filled with water while a woman lies prone on a bed. A dual-head laser (755 and 1064 nm) illuminates the breast with one...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Photo-Optical Instrumentation Engineers
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005569/ https://www.ncbi.nlm.nih.gov/pubmed/31650741 http://dx.doi.org/10.1117/1.JBO.24.12.121909 |
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author | Schoustra, Sjoukje M. Piras, Daniele Huijink, Roeland op ‘t Root, Tim J. P. M. Alink, Laurens Kobold, Wouter Muller Steenbergen, Wiendelt Manohar, Srirang |
author_facet | Schoustra, Sjoukje M. Piras, Daniele Huijink, Roeland op ‘t Root, Tim J. P. M. Alink, Laurens Kobold, Wouter Muller Steenbergen, Wiendelt Manohar, Srirang |
author_sort | Schoustra, Sjoukje M. |
collection | PubMed |
description | We present the Twente Photoacoustic Mammoscope 2, a photoacoustic breast imaging system employing a tomographic configuration. It images one breast pendant inside an imaging tank filled with water while a woman lies prone on a bed. A dual-head laser (755 and 1064 nm) illuminates the breast with one beam directed at the nipple and nine beams directed at the sides. Ultrasound signals are detected using 12 arc-shaped arrays, each curving along the pendant breast. Each array comprises 32 piezocomposite elements each with a center frequency of 1 MHz. The imaging tank and the ultrasound arrays rotate around the breast in steps to obtain additional multiple projections. Three-dimensional images are reconstructed using a filtered backprojection algorithm. The system is described in detail, and measurements on a test object are presented. As part of a preliminary study to assess the system’s in vivo performance, the breasts of two healthy volunteers were imaged. These images show the breast contour, the nipple, and the vascular anatomy within the breast. In the nipple of one case, multiple high-intensity “hot spots” are observed, which we suspect are associated with the lactiferous ducts terminating in the nipple. |
format | Online Article Text |
id | pubmed-7005569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Society of Photo-Optical Instrumentation Engineers |
record_format | MEDLINE/PubMed |
spelling | pubmed-70055692020-02-14 Twente Photoacoustic Mammoscope 2: system overview and three-dimensional vascular network images in healthy breasts Schoustra, Sjoukje M. Piras, Daniele Huijink, Roeland op ‘t Root, Tim J. P. M. Alink, Laurens Kobold, Wouter Muller Steenbergen, Wiendelt Manohar, Srirang J Biomed Opt Special Section Celebrating the Exponential Growth of Biomedical Optoacoustic/Photoacoustic Imaging We present the Twente Photoacoustic Mammoscope 2, a photoacoustic breast imaging system employing a tomographic configuration. It images one breast pendant inside an imaging tank filled with water while a woman lies prone on a bed. A dual-head laser (755 and 1064 nm) illuminates the breast with one beam directed at the nipple and nine beams directed at the sides. Ultrasound signals are detected using 12 arc-shaped arrays, each curving along the pendant breast. Each array comprises 32 piezocomposite elements each with a center frequency of 1 MHz. The imaging tank and the ultrasound arrays rotate around the breast in steps to obtain additional multiple projections. Three-dimensional images are reconstructed using a filtered backprojection algorithm. The system is described in detail, and measurements on a test object are presented. As part of a preliminary study to assess the system’s in vivo performance, the breasts of two healthy volunteers were imaged. These images show the breast contour, the nipple, and the vascular anatomy within the breast. In the nipple of one case, multiple high-intensity “hot spots” are observed, which we suspect are associated with the lactiferous ducts terminating in the nipple. Society of Photo-Optical Instrumentation Engineers 2019-10-24 2019-12 /pmc/articles/PMC7005569/ /pubmed/31650741 http://dx.doi.org/10.1117/1.JBO.24.12.121909 Text en © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. |
spellingShingle | Special Section Celebrating the Exponential Growth of Biomedical Optoacoustic/Photoacoustic Imaging Schoustra, Sjoukje M. Piras, Daniele Huijink, Roeland op ‘t Root, Tim J. P. M. Alink, Laurens Kobold, Wouter Muller Steenbergen, Wiendelt Manohar, Srirang Twente Photoacoustic Mammoscope 2: system overview and three-dimensional vascular network images in healthy breasts |
title | Twente Photoacoustic Mammoscope 2: system overview and three-dimensional vascular network images in healthy breasts |
title_full | Twente Photoacoustic Mammoscope 2: system overview and three-dimensional vascular network images in healthy breasts |
title_fullStr | Twente Photoacoustic Mammoscope 2: system overview and three-dimensional vascular network images in healthy breasts |
title_full_unstemmed | Twente Photoacoustic Mammoscope 2: system overview and three-dimensional vascular network images in healthy breasts |
title_short | Twente Photoacoustic Mammoscope 2: system overview and three-dimensional vascular network images in healthy breasts |
title_sort | twente photoacoustic mammoscope 2: system overview and three-dimensional vascular network images in healthy breasts |
topic | Special Section Celebrating the Exponential Growth of Biomedical Optoacoustic/Photoacoustic Imaging |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005569/ https://www.ncbi.nlm.nih.gov/pubmed/31650741 http://dx.doi.org/10.1117/1.JBO.24.12.121909 |
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