Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer

Somatic copy number alterations play a critical role in oncogenesis. Loss of chromosomal regions containing tumor suppressors can lead to collateral deletion of passenger genes. This can be exploited therapeutically if synthetic lethal partners of such passenger genes are known and represent druggab...

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Detalles Bibliográficos
Autores principales: Szymańska, Ewelina, Nowak, Paulina, Kolmus, Krzysztof, Cybulska, Magdalena, Goryca, Krzysztof, Derezińska‐Wołek, Edyta, Szumera‐Ciećkiewicz, Anna, Brewińska‐Olchowik, Marta, Grochowska, Aleksandra, Piwocka, Katarzyna, Prochorec‐Sobieszek, Monika, Mikula, Michał, Miączyńska, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005644/
https://www.ncbi.nlm.nih.gov/pubmed/31930723
http://dx.doi.org/10.15252/emmm.201910812

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