G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer

Triple-negative breast cancer (TNBC) is a highly metastatic and deadly disease. TNBC tumors lack estrogen receptor (ERα), progesterone receptor (PR), and HER2 (ErbB2) and exhibit increased glutamine metabolism, a requirement for tumor growth. The G protein-coupled kisspeptin receptor (KISS1R) is hig...

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Detalles Bibliográficos
Autores principales: Dragan, Magdalena, Nguyen, Mai-Uyen, Guzman, Stephania, Goertzen, Cameron, Brackstone, Muriel, Dhillo, Waljit S., Bech, Paul R., Clarke, Sophie, Abbara, Ali, Tuck, Alan B., Hess, David A., Pine, Sharon R., Zong, Wei-Xing, Wondisford, Frederic E., Su, Xiaoyang, Babwah, Andy V., Bhattacharya, Moshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005685/
https://www.ncbi.nlm.nih.gov/pubmed/32034133
http://dx.doi.org/10.1038/s41419-020-2305-7

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