Cargando…

Validating a targeted next-generation sequencing assay and profiling somatic variants in Chinese non-small cell lung cancer patients

Non-small cell lung cancer (NSCLC) is featured with complex genomic alterations. Molecular profiling of large cohort of NSCLC patients is thus a prerequisite for precision medicine. We first validated the detection performance of a next-generation sequencing (NGS) cancer hotspot panel, OncoAim, on f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Ruirui, Zhang, Bo, Teng, Xiaodong, Hu, Peizhen, Xu, Sanpeng, Zheng, Zuyu, Liu, Rui, Tang, Tingdong, Ye, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005734/ https://www.ncbi.nlm.nih.gov/pubmed/32034196 http://dx.doi.org/10.1038/s41598-020-58819-5

Ejemplares similares

Development and Validation of a Scalable Next-Generation Sequencing System for Assessing Relevant Somatic Variants in Solid Tumors()()
por: Hovelson, Daniel H., et al.
Publicado: (2015)

Clinical Targeted Next-Generation sequencing Panels for Detection of Somatic Variants in Gliomas
por: Shin, Hyemi, et al.
Publicado: (2020)

Korean Society for Genetic Diagnostics Guidelines for Validation of Next-Generation Sequencing-Based Somatic Variant Detection in Hematologic Malignancies
por: Kim, Heyjin, et al.
Publicado: (2019)

PeSV-Fisher: Identification of Somatic and Non-Somatic Structural Variants Using Next Generation Sequencing Data
por: Escaramís, Geòrgia, et al.
Publicado: (2013)

Pisces: an accurate and versatile variant caller for somatic and germline next-generation sequencing data
por: Dunn, Tamsen, et al.
Publicado: (2019)

Detection of somatic structural variants from short-read next-generation sequencing data
por: Gong, Tingting, et al.
Publicado: (2020)

Germline and somatic variants in ovarian carcinoma: A next-generation sequencing (NGS) analysis
por: Andrikopoulou, Angeliki, et al.
Publicado: (2022)

Correction: PeSV-Fisher: Identification of Somatic and Non-Somatic Structural Variants Using Next Generation Sequencing Data
por: Escaramís, Geòrgia, et al.
Publicado: (2013)

Validation of a Metagenomic Next-Generation Sequencing Assay for Lower Respiratory Pathogen Detection
por: Diao, Zhenli, et al.
Publicado: (2022)

Development and Validation of a Next-Generation Sequencing Assay for BRCA1 and BRCA2 Variants for the Clinical Laboratory
por: Strom, Charles M., et al.
Publicado: (2015)

A review of somatic single nucleotide variant calling algorithms for next-generation sequencing data
por: Xu, Chang
Publicado: (2018)

The utilization of next-generation sequencing to detect somatic mutations and predict clinical prognosis of Chinese non-small cell lung cancer patients
por: Cao, Liming, et al.
Publicado: (2018)

Validation and assessment of variant calling pipelines for next-generation sequencing
por: Pirooznia, Mehdi, et al.
Publicado: (2014)

Somatic Mutation Profiles Revealed by Next Generation Sequencing (NGS) in 39 Chinese Hepatocellular Carcinoma Patients
por: Ke, Lixin, et al.
Publicado: (2022)

Clinical validation of the tempus xT next-generation targeted oncology sequencing assay
por: Beaubier, Nike, et al.
Publicado: (2019)

Single-Center Experience with a Targeted Next Generation Sequencing Assay for Assessment of Relevant Somatic Alterations in Solid Tumors
por: Paasinen-Sohns, Aino, et al.
Publicado: (2017)

Next Generation Sequencing of Tumor and Matched Plasma Samples: Identification of Somatic Variants in ctDNA From Ovarian Cancer Patients
por: Barbosa, Ana, et al.
Publicado: (2021)

One byte at a time: evidencing the quality of clinical service next-generation sequencing for germline and somatic variants
por: Gutowska-Ding, Maria Weronika, et al.
Publicado: (2019)

Validation of a semiconductor next-generation sequencing assay for the clinical genetic screening of CFTR
por: Trujillano, Daniel, et al.
Publicado: (2015)

Validation of a Custom Next-Generation Sequencing Assay for Cystic Fibrosis Newborn Screening
por: Sicko, Robert J., et al.
Publicado: (2021)

Not All Next Generation Sequencing Diagnostics are Created Equal: Understanding the Nuances of Solid Tumor Assay Design for Somatic Mutation Detection
por: Gray, Phillip N., et al.
Publicado: (2015)

Identification of gene variants in 130 Han Chinese patients with hypospadias by targeted next‐generation sequencing
por: Zhang, Wanyu, et al.
Publicado: (2019)

Somatic variation as an incidental finding in the pediatric next-generation sequencing era
por: Melas, Marilena, et al.
Publicado: (2021)

TumorNext-Lynch-MMR: a comprehensive next generation sequencing assay for the detection of germline and somatic mutations in genes associated with mismatch repair deficiency and Lynch syndrome
por: Gray, Phillip N., et al.
Publicado: (2018)

Discovery of rare variants implicated in schizophrenia using next-generation sequencing
por: Rhoades, Raina, et al.
Publicado: (2019)

A comprehensive assessment of Next‐Generation Sequencing variants validation using a secondary technology
por: Zheng, Jianchao, et al.
Publicado: (2019)

Development and analytical validation of a next-generation sequencing based microsatellite instability (MSI) assay
por: Pabla, Sarabjot, et al.
Publicado: (2019)

SNooPer: a machine learning-based method for somatic variant identification from low-pass next-generation sequencing
por: Spinella, Jean-François, et al.
Publicado: (2016)

The landscape of somatic mutation in sporadic Chinese colorectal cancer
por: Liu, Zhe, et al.
Publicado: (2018)

Germline and somatic mutations in homologous recombination genes among Chinese ovarian cancer patients detected using next-generation sequencing
por: Zhao, Qianying, et al.
Publicado: (2017)

Barcode-free next-generation sequencing error validation for ultra-rare variant detection
por: Yeom, Huiran, et al.
Publicado: (2019)

Validation of Variant Assembly Using HAPHPIPE with Next-Generation Sequence Data from Viruses
por: Gibson, Keylie M., et al.
Publicado: (2020)

Profiling of Somatic Mutations in Phaeochromocytoma and Paraganglioma by Targeted Next Generation Sequencing Analysis
por: Luchetti, Andrea, et al.
Publicado: (2015)

Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus
por: Lim, Sun Min, et al.
Publicado: (2016)

PIK3CA somatic alterations in invasive breast cancers: different spectrum from Caucasians to Chinese detected by next generation sequencing
por: Jia, Minghan, et al.
Publicado: (2021)

Comprehensive Analysis to Improve the Validation Rate for Single Nucleotide Variants Detected by Next-Generation Sequencing
por: Park, Mi-Hyun, et al.
Publicado: (2014)

A novel machine learning approach (svmSomatic) to distinguish somatic and germline mutations using next-generation sequencing data
por: Mao, Yu-Fang, et al.
Publicado: (2021)

Estimating Exceptionally Rare Germline and Somatic Mutation Frequencies via Next Generation Sequencing
por: Eboreime, Jordan, et al.
Publicado: (2016)

The use of technical replication for detection of low-level somatic mutations in next-generation sequencing
por: Kim, Junho, et al.
Publicado: (2019)

Landscape of somatic mutations in gastric cancer assessed using next-generation sequencing analysis
por: Pan, Xuan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_g714fr0i9cs6p2ce4h94pb68n9