APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and therapeutic resistance. Mutational plasticity also drives generation of neoepitopes, which prime anti-tumor T cells. Here, we show that overexpression of APOBEC3B in tumo...

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Detalles Bibliográficos
Autores principales: Driscoll, Christopher B., Schuelke, Matthew R., Kottke, Timothy, Thompson, Jill M., Wongthida, Phonphimon, Tonne, Jason M., Huff, Amanda L., Miller, Amber, Shim, Kevin G., Molan, Amy, Wetmore, Cynthia, Selby, Peter, Samson, Adel, Harrington, Kevin, Pandha, Hardev, Melcher, Alan, Pulido, Jose S., Harris, Reuben, Evgin, Laura, Vile, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005822/
https://www.ncbi.nlm.nih.gov/pubmed/32034147
http://dx.doi.org/10.1038/s41467-020-14568-7

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