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Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis

The fatty acid synthase type II (FAS-II) multienzyme system builds the main chain of mycolic acids (MAs), important lipid pathogenicity factors of Mycobacterium tuberculosis (Mtb). Due to their original structure, the identification of the (3 R)-hydroxyacyl-ACP dehydratases, HadAB and HadBC, of Mtb...

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Detalles Bibliográficos
Autores principales:	Lefebvre, Cyril, Frigui, Wafa, Slama, Nawel, Lauzeral-Vizcaino, Françoise, Constant, Patricia, Lemassu, Anne, Parish, Tanya, Eynard, Nathalie, Daffé, Mamadou, Brosch, Roland, Quémard, Annaïk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005898/ https://www.ncbi.nlm.nih.gov/pubmed/32034201 http://dx.doi.org/10.1038/s41598-020-58967-8

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