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Change in incidence, characteristics and management of colorectal neuroendocrine tumours in the Netherlands in the last decade
BACKGROUND: Neuroendocrine tumours (NETs) are rare. However, a rising incidence has been reported over the past decades. For colorectal NETs, this is presumably caused by an increased awareness of colorectal diseases and colonoscopic procedures. This study aims to analyse the change in incidence of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006007/ https://www.ncbi.nlm.nih.gov/pubmed/32213058 http://dx.doi.org/10.1177/2050640619865113 |
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author | Kooyker, Arthur I Verbeek, Wieke HM van den Berg, José G Tesselaar, Margot ET van Leerdam, Monique E |
author_facet | Kooyker, Arthur I Verbeek, Wieke HM van den Berg, José G Tesselaar, Margot ET van Leerdam, Monique E |
author_sort | Kooyker, Arthur I |
collection | PubMed |
description | BACKGROUND: Neuroendocrine tumours (NETs) are rare. However, a rising incidence has been reported over the past decades. For colorectal NETs, this is presumably caused by an increased awareness of colorectal diseases and colonoscopic procedures. This study aims to analyse the change in incidence of colorectal NETs, characteristics and management and evaluate the proportion of colorectal NETs detected in a national colorectal cancer (CRC) screening programme. METHODS: Histopathological reports on colorectal well-differentiated NETs detected between 2006 and 2016 were collected from the Dutch pathology database (PALGA) containing nationwide histo- and cytopathology reports of all pathology laboratories in the Netherlands. RESULTS: Colorectal NETs were detected in 1055 individuals. Increasing incidence rates were observed from 0.36 per 100,000 inhabitants in 2006 to 0.75 per 100,000 inhabitants in 2011 (p value < 0.001), remaining stable afterward. Most NETs were grade I (73.5%) and detected in the rectum (76.4%). The majority (88.2%) were detected by colonoscopy, and the final intervention depended significantly on primary location of the tumour; 94.6% of rectal NETs were endoscopically removed, whereas 61.0% of colonic NETs were removed by surgery. There was an increase in local excision both of rectal and colonic NETs over the years instead of radical resection. Screening for CRC started in 2014 and contributed by detecting 32% of the diagnosed colorectal NETs within the invited age group, of which 94.6% were detected at an early stage. CONCLUSION: The incidence of reported colorectal NETs in the Netherlands doubled over the last decade. The Dutch CRC screening programme had a clear contribution to colorectal NETs incidence among its target population. A shift to more local management of detected lesions was observed over time. |
format | Online Article Text |
id | pubmed-7006007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-70060072020-02-20 Change in incidence, characteristics and management of colorectal neuroendocrine tumours in the Netherlands in the last decade Kooyker, Arthur I Verbeek, Wieke HM van den Berg, José G Tesselaar, Margot ET van Leerdam, Monique E United European Gastroenterol J Original Articles BACKGROUND: Neuroendocrine tumours (NETs) are rare. However, a rising incidence has been reported over the past decades. For colorectal NETs, this is presumably caused by an increased awareness of colorectal diseases and colonoscopic procedures. This study aims to analyse the change in incidence of colorectal NETs, characteristics and management and evaluate the proportion of colorectal NETs detected in a national colorectal cancer (CRC) screening programme. METHODS: Histopathological reports on colorectal well-differentiated NETs detected between 2006 and 2016 were collected from the Dutch pathology database (PALGA) containing nationwide histo- and cytopathology reports of all pathology laboratories in the Netherlands. RESULTS: Colorectal NETs were detected in 1055 individuals. Increasing incidence rates were observed from 0.36 per 100,000 inhabitants in 2006 to 0.75 per 100,000 inhabitants in 2011 (p value < 0.001), remaining stable afterward. Most NETs were grade I (73.5%) and detected in the rectum (76.4%). The majority (88.2%) were detected by colonoscopy, and the final intervention depended significantly on primary location of the tumour; 94.6% of rectal NETs were endoscopically removed, whereas 61.0% of colonic NETs were removed by surgery. There was an increase in local excision both of rectal and colonic NETs over the years instead of radical resection. Screening for CRC started in 2014 and contributed by detecting 32% of the diagnosed colorectal NETs within the invited age group, of which 94.6% were detected at an early stage. CONCLUSION: The incidence of reported colorectal NETs in the Netherlands doubled over the last decade. The Dutch CRC screening programme had a clear contribution to colorectal NETs incidence among its target population. A shift to more local management of detected lesions was observed over time. SAGE Publications 2019-07-15 2020-02 /pmc/articles/PMC7006007/ /pubmed/32213058 http://dx.doi.org/10.1177/2050640619865113 Text en © Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Kooyker, Arthur I Verbeek, Wieke HM van den Berg, José G Tesselaar, Margot ET van Leerdam, Monique E Change in incidence, characteristics and management of colorectal neuroendocrine tumours in the Netherlands in the last decade |
title | Change in incidence, characteristics and management of colorectal
neuroendocrine tumours in the Netherlands in the last decade |
title_full | Change in incidence, characteristics and management of colorectal
neuroendocrine tumours in the Netherlands in the last decade |
title_fullStr | Change in incidence, characteristics and management of colorectal
neuroendocrine tumours in the Netherlands in the last decade |
title_full_unstemmed | Change in incidence, characteristics and management of colorectal
neuroendocrine tumours in the Netherlands in the last decade |
title_short | Change in incidence, characteristics and management of colorectal
neuroendocrine tumours in the Netherlands in the last decade |
title_sort | change in incidence, characteristics and management of colorectal
neuroendocrine tumours in the netherlands in the last decade |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006007/ https://www.ncbi.nlm.nih.gov/pubmed/32213058 http://dx.doi.org/10.1177/2050640619865113 |
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