Cargando…

Complement Activation Is Associated With Mortality in Patients With Necrotizing Soft-Tissue Infections—A Prospective Observational Study

Aim: We assessed whether different complement factors and complement activation products were associated with poor outcome in patients with necrotizing soft-tissue infection (NSTI). Methods: We conducted a prospective, observational study in an intensive care unit where treatment of NSTI is centrali...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kristensen, Markus Korsholm, Hansen, Marco Bo, Madsen, Martin Bruun, Hansen, Cecilie Bo, Pilely, Katrine, Hyldegaard, Ole, Garred, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006023/ https://www.ncbi.nlm.nih.gov/pubmed/32082310 http://dx.doi.org/10.3389/fimmu.2020.00017

Ejemplares similares

Increase in the Complement Activation Product C4d and the Terminal Complement Complex sC5b-9 Is Associated with Disease Severity and a Fatal Outcome in Necrotizing Soft-Tissue Infection
por: Hedetoft, Morten, et al.
Publicado: (2021)

Pentraxin-3 as a marker of disease severity and risk of death in patients with necrotizing soft tissue infections: a nationwide, prospective, observational study
por: Hansen, Marco Bo, et al.
Publicado: (2016)

Associations of Plasma Nitrite, l-Arginine and Asymmetric Dimethylarginine With Morbidity and Mortality in Patients With Necrotizing Soft Tissue Infections
por: Hansen, Marco B., et al.
Publicado: (2018)

Hyperbaric oxygen treatment is associated with a decrease in cytokine levels in patients with necrotizing soft‐tissue infection
por: Hedetoft, Morten, et al.
Publicado: (2021)

Associations between YKL-40 and markers of disease severity and death in patients with necrotizing soft-tissue infection
por: Hedetoft, Morten, et al.
Publicado: (2021)

Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus
por: Rosbjerg, Anne, et al.
Publicado: (2016)

Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities
por: Hertz, Cecilie E., et al.
Publicado: (2018)

Biomarkers of necrotising soft tissue infections: aspects of the innate immune response and effects of hyperbaric oxygenation—the protocol of the prospective cohort BIONEC study
por: Hansen, Marco Bo, et al.
Publicado: (2015)

Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: a multicentre, prospective study
por: Hansen, Marco Bo, et al.
Publicado: (2017)

Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study
por: Bruun, Trond, et al.
Publicado: (2020)

Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus
por: Barkai, László József, et al.
Publicado: (2019)

C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques
por: Pilely, Katrine, et al.
Publicado: (2017)

Evasion Mechanisms Used by Pathogens to Escape the Lectin Complement Pathway
por: Rosbjerg, Anne, et al.
Publicado: (2017)

Incidence, comorbidity and mortality in patients with necrotising soft-tissue infections, 2005–2018: a Danish nationwide register-based cohort study
por: Hedetoft, Morten, et al.
Publicado: (2020)

SuPAR correlates with mortality and clinical severity in patients with necrotizing soft-tissue infections: results from a prospective, observational cohort study
por: Polzik, Peter, et al.
Publicado: (2019)

SARS-CoV-2 Antibodies Mediate Complement and Cellular Driven Inflammation
por: Jarlhelt, Ida, et al.
Publicado: (2021)

Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections
por: Thänert, Robert, et al.
Publicado: (2019)

Complement factors C4 and C3 are down regulated in response to short term overfeeding in healthy young men
por: Foghmar, Caroline, et al.
Publicado: (2017)

Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections
por: Palma Medina, Laura M., et al.
Publicado: (2021)

Hyperbaric oxygen treatment in the management of necrotising soft-tissue infections: results from a Danish nationwide registry study
por: Hedetoft, Morten, et al.
Publicado: (2023)

Pentraxins in Complement Activation and Regulation
por: Ma, Ying Jie, et al.
Publicado: (2018)

Complement Nomenclature—Deconvoluted
por: Bohlson, Suzanne S., et al.
Publicado: (2019)

Hyperbaric oxygen treatment impacts oxidative stress markers in patients with necrotizing soft-tissue infection
por: Hedetoft, Morten, et al.
Publicado: (2021)

Complement Profiles in Patients with Amyotrophic Lateral Sclerosis: A Prospective Observational Cohort Study
por: Kjældgaard, Anne-Lene, et al.
Publicado: (2021)

Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19
por: Götz, Maximilian Peter, et al.
Publicado: (2022)

Functional Effects of Receptor-Binding Domain Mutations of SARS-CoV-2 B.1.351 and P.1 Variants
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2021)

The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2021)

Persistent Intracellular Staphylococcus aureus in Keratinocytes Lead to Activation of the Complement System with Subsequent Reduction in the Intracellular Bacterial Load
por: Abu-Humaidan, Anas H., et al.
Publicado: (2018)

Investigating the Effects of Hyperbaric Oxygen Treatment in Necrotizing Soft Tissue Infection With Transcriptomics and Machine Learning (the HBOmic Study): Protocol for a Prospective Cohort Study With Data Validation
por: Vinkel, Julie, et al.
Publicado: (2022)

Key pathways and genes that are altered during treatment with hyperbaric oxygen in patients with sepsis due to necrotizing soft tissue infection (HBOmic study)
por: Vinkel, Julie, et al.
Publicado: (2023)

Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse
por: Chella Krishnan, Karthickeyan, et al.
Publicado: (2016)

Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production
por: Westman, Johannes, et al.
Publicado: (2018)

Omics-Based Approach Reveals Complement-Mediated Inflammation in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)
por: Blaabjerg, Morten, et al.
Publicado: (2018)

The Lectin Complement Pathway Is Involved in Protection Against Enteroaggregative Escherichia coli Infection
por: Adler Sørensen, Camilla, et al.
Publicado: (2018)

Complement Receptor 2 Based Immunoassay Measuring Activation of the Complement System at C3-Level in Plasma Samples From Mice and Humans
por: Halkjær, Lene, et al.
Publicado: (2020)

A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein
por: Yatime, Laure, et al.
Publicado: (2018)

Distinct Roles of Classical and Lectin Pathways of Complement in Preeclamptic Placentae
por: Belmonte, Beatrice, et al.
Publicado: (2022)

Determinants of Mortality in Necrotizing Soft Tissue Infections
por: Kumar, Tarun, et al.
Publicado: (2021)

Lectin Pathway of Complement Activation Is Associated with Vulnerability of Atherosclerotic Plaques
por: Fumagalli, Stefano, et al.
Publicado: (2017)

Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report
por: Kongsbak-Wismann, Martin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v2bs3ehkjfuv9qthre37l1qvtu