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Multidiameter single-fiber reflectance spectroscopy of heavily pigmented skin: modeling the inhomogeneous distribution of melanin
When analyzing multidiameter single-fiber reflectance (MDSFR) spectra, the inhomogeneous distribution of melanin pigments in skin tissue is usually not accounted for. Especially in heavily pigmented skins, this can result in bad fits and biased estimation of tissue optical properties. A model is int...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Photo-Optical Instrumentation Engineers
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006040/ https://www.ncbi.nlm.nih.gov/pubmed/31820596 http://dx.doi.org/10.1117/1.JBO.24.12.127001 |
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author | Zhang, Xu U. van der Zee, Piet Atzeni, Isabella Faber, Dirk J. van Leeuwen, Ton G. Sterenborg, Henricus J. C. M. |
author_facet | Zhang, Xu U. van der Zee, Piet Atzeni, Isabella Faber, Dirk J. van Leeuwen, Ton G. Sterenborg, Henricus J. C. M. |
author_sort | Zhang, Xu U. |
collection | PubMed |
description | When analyzing multidiameter single-fiber reflectance (MDSFR) spectra, the inhomogeneous distribution of melanin pigments in skin tissue is usually not accounted for. Especially in heavily pigmented skins, this can result in bad fits and biased estimation of tissue optical properties. A model is introduced to account for the inhomogeneous distribution of melanin pigments in skin tissue. In vivo visible MDSFR measurements were performed on heavily pigmented skin of type IV to VI. Skin tissue optical properties and related physiological properties were extracted from the measured spectra using the introduced model. The absorption of melanin pigments described by the introduced model demonstrates a good correlation with the co-localized measurement of the well-known melanin index. |
format | Online Article Text |
id | pubmed-7006040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Society of Photo-Optical Instrumentation Engineers |
record_format | MEDLINE/PubMed |
spelling | pubmed-70060402020-02-14 Multidiameter single-fiber reflectance spectroscopy of heavily pigmented skin: modeling the inhomogeneous distribution of melanin Zhang, Xu U. van der Zee, Piet Atzeni, Isabella Faber, Dirk J. van Leeuwen, Ton G. Sterenborg, Henricus J. C. M. J Biomed Opt Sensing When analyzing multidiameter single-fiber reflectance (MDSFR) spectra, the inhomogeneous distribution of melanin pigments in skin tissue is usually not accounted for. Especially in heavily pigmented skins, this can result in bad fits and biased estimation of tissue optical properties. A model is introduced to account for the inhomogeneous distribution of melanin pigments in skin tissue. In vivo visible MDSFR measurements were performed on heavily pigmented skin of type IV to VI. Skin tissue optical properties and related physiological properties were extracted from the measured spectra using the introduced model. The absorption of melanin pigments described by the introduced model demonstrates a good correlation with the co-localized measurement of the well-known melanin index. Society of Photo-Optical Instrumentation Engineers 2019-12-09 2019-12 /pmc/articles/PMC7006040/ /pubmed/31820596 http://dx.doi.org/10.1117/1.JBO.24.12.127001 Text en © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. |
spellingShingle | Sensing Zhang, Xu U. van der Zee, Piet Atzeni, Isabella Faber, Dirk J. van Leeuwen, Ton G. Sterenborg, Henricus J. C. M. Multidiameter single-fiber reflectance spectroscopy of heavily pigmented skin: modeling the inhomogeneous distribution of melanin |
title | Multidiameter single-fiber reflectance spectroscopy of heavily pigmented skin: modeling the inhomogeneous distribution of melanin |
title_full | Multidiameter single-fiber reflectance spectroscopy of heavily pigmented skin: modeling the inhomogeneous distribution of melanin |
title_fullStr | Multidiameter single-fiber reflectance spectroscopy of heavily pigmented skin: modeling the inhomogeneous distribution of melanin |
title_full_unstemmed | Multidiameter single-fiber reflectance spectroscopy of heavily pigmented skin: modeling the inhomogeneous distribution of melanin |
title_short | Multidiameter single-fiber reflectance spectroscopy of heavily pigmented skin: modeling the inhomogeneous distribution of melanin |
title_sort | multidiameter single-fiber reflectance spectroscopy of heavily pigmented skin: modeling the inhomogeneous distribution of melanin |
topic | Sensing |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006040/ https://www.ncbi.nlm.nih.gov/pubmed/31820596 http://dx.doi.org/10.1117/1.JBO.24.12.127001 |
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