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Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia

BACKGROUND: Preeclampsia (PE) is a serious complication of pregnancy and one of the main causes of maternal and neonatal mortality and morbidity in the world. Finding a biomarker with high sensitivity and specificity could lead to prediction and early diagnosis of the disease and reduces its complic...

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Autores principales: Nikuei, Pooneh, Rajaei, Minoo, Roozbeh, Nasibeh, Mohseni, Fatemeh, Poordarvishi, Fatemeh, Azad, Mohsen, Haidari, Solmaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006116/
https://www.ncbi.nlm.nih.gov/pubmed/32033594
http://dx.doi.org/10.1186/s12884-020-2744-2
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author Nikuei, Pooneh
Rajaei, Minoo
Roozbeh, Nasibeh
Mohseni, Fatemeh
Poordarvishi, Fatemeh
Azad, Mohsen
Haidari, Solmaz
author_facet Nikuei, Pooneh
Rajaei, Minoo
Roozbeh, Nasibeh
Mohseni, Fatemeh
Poordarvishi, Fatemeh
Azad, Mohsen
Haidari, Solmaz
author_sort Nikuei, Pooneh
collection PubMed
description BACKGROUND: Preeclampsia (PE) is a serious complication of pregnancy and one of the main causes of maternal and neonatal mortality and morbidity in the world. Finding a biomarker with high sensitivity and specificity could lead to prediction and early diagnosis of the disease and reduces its complications. In this study, we evaluated diagnostic accuracy of Soluble fms-like tyrosine kinase-1 (sFlt-1) to Placental growth factor (PlGF) ratio for diagnosis of PE. METHODS: The cases included 23 mild, 15 severe preeclamptic patients, and 20 normal term pregnant women as control referred to GYN ward of the Persian Gulf Hospital in Bandar Abbas from 2014 to 2016. Levels of sFlt-1 and PlGF were measured. Receiver Operating Characteristic (ROC) curve analysis was applied to calculate diagnostic accuracy of sFlt-1/PlGF ratio. RESULTS: The mean Level of sFlt-1/PlGF in PE patients (91.33 ng/ml) was significantly higher than control women (17.62) (P<0.001). ROC curve analysis showed sFlt-1/PlGF ratio diagnostic accuracy in preeclamptic patients with Area Under Curve (AUC) of 0.90, the best cut-off value of 24.96, sensitivity and specificity of 84.2 and 85.0%, respectively. CONCLUSIONS: Our data showed sFlt-1/PlGF ratio has higher accuracy for differentiating PE patients from non-PEs in comparison with its power for differentiating severe or early onset forms of the disease.
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spelling pubmed-70061162020-02-11 Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia Nikuei, Pooneh Rajaei, Minoo Roozbeh, Nasibeh Mohseni, Fatemeh Poordarvishi, Fatemeh Azad, Mohsen Haidari, Solmaz BMC Pregnancy Childbirth Research Article BACKGROUND: Preeclampsia (PE) is a serious complication of pregnancy and one of the main causes of maternal and neonatal mortality and morbidity in the world. Finding a biomarker with high sensitivity and specificity could lead to prediction and early diagnosis of the disease and reduces its complications. In this study, we evaluated diagnostic accuracy of Soluble fms-like tyrosine kinase-1 (sFlt-1) to Placental growth factor (PlGF) ratio for diagnosis of PE. METHODS: The cases included 23 mild, 15 severe preeclamptic patients, and 20 normal term pregnant women as control referred to GYN ward of the Persian Gulf Hospital in Bandar Abbas from 2014 to 2016. Levels of sFlt-1 and PlGF were measured. Receiver Operating Characteristic (ROC) curve analysis was applied to calculate diagnostic accuracy of sFlt-1/PlGF ratio. RESULTS: The mean Level of sFlt-1/PlGF in PE patients (91.33 ng/ml) was significantly higher than control women (17.62) (P<0.001). ROC curve analysis showed sFlt-1/PlGF ratio diagnostic accuracy in preeclamptic patients with Area Under Curve (AUC) of 0.90, the best cut-off value of 24.96, sensitivity and specificity of 84.2 and 85.0%, respectively. CONCLUSIONS: Our data showed sFlt-1/PlGF ratio has higher accuracy for differentiating PE patients from non-PEs in comparison with its power for differentiating severe or early onset forms of the disease. BioMed Central 2020-02-07 /pmc/articles/PMC7006116/ /pubmed/32033594 http://dx.doi.org/10.1186/s12884-020-2744-2 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Nikuei, Pooneh
Rajaei, Minoo
Roozbeh, Nasibeh
Mohseni, Fatemeh
Poordarvishi, Fatemeh
Azad, Mohsen
Haidari, Solmaz
Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia
title Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia
title_full Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia
title_fullStr Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia
title_full_unstemmed Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia
title_short Diagnostic accuracy of sFlt1/PlGF ratio as a marker for preeclampsia
title_sort diagnostic accuracy of sflt1/plgf ratio as a marker for preeclampsia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006116/
https://www.ncbi.nlm.nih.gov/pubmed/32033594
http://dx.doi.org/10.1186/s12884-020-2744-2
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