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Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol
BACKGROUND: Uterine receptivity is one of the determinants of embryo implantation, which is responsible for pregnancy success. Aberrant embryo implantation due to disrupted uterine receptivity is usually found in ovarian hyperstimulation induced hyperoestrogen patients. RESULTS: This study identifie...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006210/ https://www.ncbi.nlm.nih.gov/pubmed/32028879 http://dx.doi.org/10.1186/s12861-020-0208-6 |
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author | Zhang, He Zhao, Huashan Wang, Xi Cui, Xiaolin Jin, Lingling |
author_facet | Zhang, He Zhao, Huashan Wang, Xi Cui, Xiaolin Jin, Lingling |
author_sort | Zhang, He |
collection | PubMed |
description | BACKGROUND: Uterine receptivity is one of the determinants of embryo implantation, which is responsible for pregnancy success. Aberrant embryo implantation due to disrupted uterine receptivity is usually found in ovarian hyperstimulation induced hyperoestrogen patients. RESULTS: This study identified keratin 86 (KRT86), a fibrous structural protein, which was upregulated in uterine endometrium during peri-implantation. Using a hyperoestrogen mouse model established in a previous study, we found abnormal oestradiol (E2) levels during pre-implantation could trigger high expression of Krt86 in the uterine epithelium. In an ovariectomised mouse model, combining oestrogen receptors ERα and ERβ knockout mice models, uterine Krt86 was found to be up-regulated after E2 treatment, mediated by nuclear ERα. Furthermore, we found progesterone (P4) could ameliorate Krt86 expression, induced by abnormal E2. CONCLUSIONS: These results revealed the dynamic expression and regulation of Krt86, especially in hyperoestrogen treated mice, indicating it might act as a marker for non-receptive uterus. |
format | Online Article Text |
id | pubmed-7006210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70062102020-02-11 Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol Zhang, He Zhao, Huashan Wang, Xi Cui, Xiaolin Jin, Lingling BMC Dev Biol Research Article BACKGROUND: Uterine receptivity is one of the determinants of embryo implantation, which is responsible for pregnancy success. Aberrant embryo implantation due to disrupted uterine receptivity is usually found in ovarian hyperstimulation induced hyperoestrogen patients. RESULTS: This study identified keratin 86 (KRT86), a fibrous structural protein, which was upregulated in uterine endometrium during peri-implantation. Using a hyperoestrogen mouse model established in a previous study, we found abnormal oestradiol (E2) levels during pre-implantation could trigger high expression of Krt86 in the uterine epithelium. In an ovariectomised mouse model, combining oestrogen receptors ERα and ERβ knockout mice models, uterine Krt86 was found to be up-regulated after E2 treatment, mediated by nuclear ERα. Furthermore, we found progesterone (P4) could ameliorate Krt86 expression, induced by abnormal E2. CONCLUSIONS: These results revealed the dynamic expression and regulation of Krt86, especially in hyperoestrogen treated mice, indicating it might act as a marker for non-receptive uterus. BioMed Central 2020-02-07 /pmc/articles/PMC7006210/ /pubmed/32028879 http://dx.doi.org/10.1186/s12861-020-0208-6 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zhang, He Zhao, Huashan Wang, Xi Cui, Xiaolin Jin, Lingling Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
title | Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
title_full | Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
title_fullStr | Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
title_full_unstemmed | Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
title_short | Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
title_sort | keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006210/ https://www.ncbi.nlm.nih.gov/pubmed/32028879 http://dx.doi.org/10.1186/s12861-020-0208-6 |
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