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Reproductive Toxicity Evaluation of Pestban Insecticide Exposure in Male and Female Rats
Sexually mature male and female rats were orally intubated with the organophosphorus insecticide, Pestban at a daily dosage of 7.45 or 3.72 mg/kg bwt, equivalent to 1/20 and 1/40 LD50, respectively. Male rats were exposed for 70 days, while the female rats were exposed for 14 days, premating, during...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006254/ https://www.ncbi.nlm.nih.gov/pubmed/32038788 http://dx.doi.org/10.5487/TR.2008.24.2.137 |
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author | Morgan, Ashraf M. Abd El-Aty, A. M. |
author_facet | Morgan, Ashraf M. Abd El-Aty, A. M. |
author_sort | Morgan, Ashraf M. |
collection | PubMed |
description | Sexually mature male and female rats were orally intubated with the organophosphorus insecticide, Pestban at a daily dosage of 7.45 or 3.72 mg/kg bwt, equivalent to 1/20 and 1/40 LD50, respectively. Male rats were exposed for 70 days, while the female rats were exposed for 14 days, premating, during mating and throughout the whole length of gestation and lactation periods till weaning. The results showed depressed acetylcholinesterase (AChE) activity in the brain of parents, fetuses and their placentae in a dose-dependent manner. The fertility was significantly reduced with increasing the dose in both treated groups, with more pronounced suppressive effects in the male treated group. The number of implantation sites and viable fetuses were significantly reduced in pregnant females of both treated groups. However, the number of resorptions, dead fetuses, and pre-and postimplantation losses were significantly increased. The incidence of resorptions was more pronounced in treated female compared to male group and was dose dependant. The behavioral responses as well as fetal survival and viability indices were altered in both treated groups during the lactation period. The incidence of these effects was more pronounced in the treated female group and occurred in a dose-related manner. The recorded morphological, visceral, and skeletal anomalies were significantly increased with increasing the dose in fetuses of both treated groups, with more pronounced effects on fetuses of treated females. In conclusion, the exposure of adult male and female rats to Pestban would cause adverse effects on fertility and reproduction. |
format | Online Article Text |
id | pubmed-7006254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-70062542020-02-07 Reproductive Toxicity Evaluation of Pestban Insecticide Exposure in Male and Female Rats Morgan, Ashraf M. Abd El-Aty, A. M. Toxicol Res Article Sexually mature male and female rats were orally intubated with the organophosphorus insecticide, Pestban at a daily dosage of 7.45 or 3.72 mg/kg bwt, equivalent to 1/20 and 1/40 LD50, respectively. Male rats were exposed for 70 days, while the female rats were exposed for 14 days, premating, during mating and throughout the whole length of gestation and lactation periods till weaning. The results showed depressed acetylcholinesterase (AChE) activity in the brain of parents, fetuses and their placentae in a dose-dependent manner. The fertility was significantly reduced with increasing the dose in both treated groups, with more pronounced suppressive effects in the male treated group. The number of implantation sites and viable fetuses were significantly reduced in pregnant females of both treated groups. However, the number of resorptions, dead fetuses, and pre-and postimplantation losses were significantly increased. The incidence of resorptions was more pronounced in treated female compared to male group and was dose dependant. The behavioral responses as well as fetal survival and viability indices were altered in both treated groups during the lactation period. The incidence of these effects was more pronounced in the treated female group and occurred in a dose-related manner. The recorded morphological, visceral, and skeletal anomalies were significantly increased with increasing the dose in fetuses of both treated groups, with more pronounced effects on fetuses of treated females. In conclusion, the exposure of adult male and female rats to Pestban would cause adverse effects on fertility and reproduction. Springer Singapore 2008-06-01 2008-06 /pmc/articles/PMC7006254/ /pubmed/32038788 http://dx.doi.org/10.5487/TR.2008.24.2.137 Text en © Korean Society of Toxicology 2008 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Morgan, Ashraf M. Abd El-Aty, A. M. Reproductive Toxicity Evaluation of Pestban Insecticide Exposure in Male and Female Rats |
title | Reproductive Toxicity Evaluation of Pestban Insecticide Exposure in Male and Female Rats |
title_full | Reproductive Toxicity Evaluation of Pestban Insecticide Exposure in Male and Female Rats |
title_fullStr | Reproductive Toxicity Evaluation of Pestban Insecticide Exposure in Male and Female Rats |
title_full_unstemmed | Reproductive Toxicity Evaluation of Pestban Insecticide Exposure in Male and Female Rats |
title_short | Reproductive Toxicity Evaluation of Pestban Insecticide Exposure in Male and Female Rats |
title_sort | reproductive toxicity evaluation of pestban insecticide exposure in male and female rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006254/ https://www.ncbi.nlm.nih.gov/pubmed/32038788 http://dx.doi.org/10.5487/TR.2008.24.2.137 |
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