Cargando…
Increased Gene Expression in Cultured BEAS-2B Cells Treated with Metal Oxide Nanoparticles
Recent publications showed that metal nanoparticles which are made from TiO(2), CeO(2), Al(2)O(3), CuCl(2), AgNO(3) and ZnO(2) induced oxidative stress and pro-inflammatory effects in cultured cells and the responses seemed to be common toxic pathway of metal nanoparticles to the ultimate toxicity i...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006314/ https://www.ncbi.nlm.nih.gov/pubmed/32038838 http://dx.doi.org/10.5487/TR.2009.25.4.195 |
_version_ | 1783495118889680896 |
---|---|
author | Park, Eun-Jung Park, Kwangsik |
author_facet | Park, Eun-Jung Park, Kwangsik |
author_sort | Park, Eun-Jung |
collection | PubMed |
description | Recent publications showed that metal nanoparticles which are made from TiO(2), CeO(2), Al(2)O(3), CuCl(2), AgNO(3) and ZnO(2) induced oxidative stress and pro-inflammatory effects in cultured cells and the responses seemed to be common toxic pathway of metal nanoparticles to the ultimate toxicity in animals as well as cellular level. In this study, we compared the gene expression induced by two different types of metal oxide nanoparticles, titanium dioxide nanoparticles (TNP) and cerium dioxide nanoparticles (CNP) using microarray analysis. About 50 genes including interleukin 6, interleukin 1, platelet-derived growth factor β, and leukemia inhibitory factor were induced in cultured BEAS-2B cells treated with TNP 40 ppm. When we compared the induction levels of genes in TNP-treated cells to those in CNP-treated cells, the induction levels were very correlated in various gene categories (r = 0.645). This may suggest a possible common toxic mechanism of metal oxide nanoparticles. |
format | Online Article Text |
id | pubmed-7006314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-70063142020-02-07 Increased Gene Expression in Cultured BEAS-2B Cells Treated with Metal Oxide Nanoparticles Park, Eun-Jung Park, Kwangsik Toxicol Res Article Recent publications showed that metal nanoparticles which are made from TiO(2), CeO(2), Al(2)O(3), CuCl(2), AgNO(3) and ZnO(2) induced oxidative stress and pro-inflammatory effects in cultured cells and the responses seemed to be common toxic pathway of metal nanoparticles to the ultimate toxicity in animals as well as cellular level. In this study, we compared the gene expression induced by two different types of metal oxide nanoparticles, titanium dioxide nanoparticles (TNP) and cerium dioxide nanoparticles (CNP) using microarray analysis. About 50 genes including interleukin 6, interleukin 1, platelet-derived growth factor β, and leukemia inhibitory factor were induced in cultured BEAS-2B cells treated with TNP 40 ppm. When we compared the induction levels of genes in TNP-treated cells to those in CNP-treated cells, the induction levels were very correlated in various gene categories (r = 0.645). This may suggest a possible common toxic mechanism of metal oxide nanoparticles. Springer Singapore 2009-12-30 2009-12 /pmc/articles/PMC7006314/ /pubmed/32038838 http://dx.doi.org/10.5487/TR.2009.25.4.195 Text en © Korean Society of Toxicology 2009 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Park, Eun-Jung Park, Kwangsik Increased Gene Expression in Cultured BEAS-2B Cells Treated with Metal Oxide Nanoparticles |
title | Increased Gene Expression in Cultured BEAS-2B Cells Treated with Metal Oxide Nanoparticles |
title_full | Increased Gene Expression in Cultured BEAS-2B Cells Treated with Metal Oxide Nanoparticles |
title_fullStr | Increased Gene Expression in Cultured BEAS-2B Cells Treated with Metal Oxide Nanoparticles |
title_full_unstemmed | Increased Gene Expression in Cultured BEAS-2B Cells Treated with Metal Oxide Nanoparticles |
title_short | Increased Gene Expression in Cultured BEAS-2B Cells Treated with Metal Oxide Nanoparticles |
title_sort | increased gene expression in cultured beas-2b cells treated with metal oxide nanoparticles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006314/ https://www.ncbi.nlm.nih.gov/pubmed/32038838 http://dx.doi.org/10.5487/TR.2009.25.4.195 |
work_keys_str_mv | AT parkeunjung increasedgeneexpressioninculturedbeas2bcellstreatedwithmetaloxidenanoparticles AT parkkwangsik increasedgeneexpressioninculturedbeas2bcellstreatedwithmetaloxidenanoparticles |