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Antidiabetic Effects of Corni Fructus Extract on Blood Glucose and Insulin Resistance in db/db Mice

This study investigated the effect of Corni Fructus (Cornus officinalis Sieb, et Zucc.) extract on blood glucose and insulin resistance in db/db mice. Seven weeks old male mice were divided into normal control group (NC), diabetic control group (DC) and Corni Fructus treated diabetic group (DCF). Ov...

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Autores principales: Kim, Hye Jeong, Kim, Kil-Soo, Lee, Tae-Jong, Kim, Young Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006319/
https://www.ncbi.nlm.nih.gov/pubmed/32038825
http://dx.doi.org/10.5487/TR.2009.25.2.093
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author Kim, Hye Jeong
Kim, Kil-Soo
Lee, Tae-Jong
Kim, Young Chul
author_facet Kim, Hye Jeong
Kim, Kil-Soo
Lee, Tae-Jong
Kim, Young Chul
author_sort Kim, Hye Jeong
collection PubMed
description This study investigated the effect of Corni Fructus (Cornus officinalis Sieb, et Zucc.) extract on blood glucose and insulin resistance in db/db mice. Seven weeks old male mice were divided into normal control group (NC), diabetic control group (DC) and Corni Fructus treated diabetic group (DCF). Over an 8-week experimental period, Corni Fructus extract was administered orally at 500 mg/kg BW/day. Corni Fructus inhibited increase in blood glucose level during the OGTT (oral glucose tolerance test). At 8 weeks after beginning of the experiment, blood glucose level in the DCF group was significantly lower (p<0.01) than the DC group. Final fasting serum glucose and triglyceride in the DCF group were significantly lower (p<0.05) than the DC group by 32% and 41% respectively. Serum insulin did not differ among the NC, DC and DCF groups. The mRNA expression of adiponectin, GLUT 4 and PPAR-γ in adipose tissue in the DC group were significantly lower than the NC group and they were higher in the DCF group than the DC group by 76%, 130% (p<0.05) and 43%, respectively. In conclusion, these results indicated that Corni Fructus would have antidiabetic effects via improving insulin resistance in favor of higher glucose utilization and reducing blood glucose level in db/db mice.
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spelling pubmed-70063192020-02-07 Antidiabetic Effects of Corni Fructus Extract on Blood Glucose and Insulin Resistance in db/db Mice Kim, Hye Jeong Kim, Kil-Soo Lee, Tae-Jong Kim, Young Chul Toxicol Res Article This study investigated the effect of Corni Fructus (Cornus officinalis Sieb, et Zucc.) extract on blood glucose and insulin resistance in db/db mice. Seven weeks old male mice were divided into normal control group (NC), diabetic control group (DC) and Corni Fructus treated diabetic group (DCF). Over an 8-week experimental period, Corni Fructus extract was administered orally at 500 mg/kg BW/day. Corni Fructus inhibited increase in blood glucose level during the OGTT (oral glucose tolerance test). At 8 weeks after beginning of the experiment, blood glucose level in the DCF group was significantly lower (p<0.01) than the DC group. Final fasting serum glucose and triglyceride in the DCF group were significantly lower (p<0.05) than the DC group by 32% and 41% respectively. Serum insulin did not differ among the NC, DC and DCF groups. The mRNA expression of adiponectin, GLUT 4 and PPAR-γ in adipose tissue in the DC group were significantly lower than the NC group and they were higher in the DCF group than the DC group by 76%, 130% (p<0.05) and 43%, respectively. In conclusion, these results indicated that Corni Fructus would have antidiabetic effects via improving insulin resistance in favor of higher glucose utilization and reducing blood glucose level in db/db mice. Springer Singapore 2009-06-01 2009-06 /pmc/articles/PMC7006319/ /pubmed/32038825 http://dx.doi.org/10.5487/TR.2009.25.2.093 Text en © Korean Society of Toxicology 2008 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Hye Jeong
Kim, Kil-Soo
Lee, Tae-Jong
Kim, Young Chul
Antidiabetic Effects of Corni Fructus Extract on Blood Glucose and Insulin Resistance in db/db Mice
title Antidiabetic Effects of Corni Fructus Extract on Blood Glucose and Insulin Resistance in db/db Mice
title_full Antidiabetic Effects of Corni Fructus Extract on Blood Glucose and Insulin Resistance in db/db Mice
title_fullStr Antidiabetic Effects of Corni Fructus Extract on Blood Glucose and Insulin Resistance in db/db Mice
title_full_unstemmed Antidiabetic Effects of Corni Fructus Extract on Blood Glucose and Insulin Resistance in db/db Mice
title_short Antidiabetic Effects of Corni Fructus Extract on Blood Glucose and Insulin Resistance in db/db Mice
title_sort antidiabetic effects of corni fructus extract on blood glucose and insulin resistance in db/db mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006319/
https://www.ncbi.nlm.nih.gov/pubmed/32038825
http://dx.doi.org/10.5487/TR.2009.25.2.093
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