Micronucleus Test of Polycan™, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice

In this research the genotoxic effect of Polycan™ β-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. Polycan™ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used...

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Detalles Bibliográficos
Autores principales: Lee, Hyeung-Sik, Cho, Hyung-Rae, Yang, Kun-Ju, Moon, Seung-Bae, Park, Bok-Ryeon, Shin, Hyun-Dong, Jang, Hee-Jeong, Kim, Lin-Su, Ku, Sae-Kwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006344/
https://www.ncbi.nlm.nih.gov/pubmed/32038771
http://dx.doi.org/10.5487/TR.2008.24.1.011
Descripción
Sumario:In this research the genotoxic effect of Polycan™ β-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. Polycan™ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that Polycan™ shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of Polycan™ tested in this study because the polychromatic erythrocyte ratio was detected as > 0.47 in all tested groups.

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