Micronucleus Test of Polycan™, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice

In this research the genotoxic effect of Polycan™ β-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. Polycan™ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used...

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Autores principales: Lee, Hyeung-Sik, Cho, Hyung-Rae, Yang, Kun-Ju, Moon, Seung-Bae, Park, Bok-Ryeon, Shin, Hyun-Dong, Jang, Hee-Jeong, Kim, Lin-Su, Ku, Sae-Kwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2008
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006344/
https://www.ncbi.nlm.nih.gov/pubmed/32038771
http://dx.doi.org/10.5487/TR.2008.24.1.011
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author Lee, Hyeung-Sik
Cho, Hyung-Rae
Yang, Kun-Ju
Moon, Seung-Bae
Park, Bok-Ryeon
Shin, Hyun-Dong
Jang, Hee-Jeong
Kim, Lin-Su
Ku, Sae-Kwang
author_facet Lee, Hyeung-Sik
Cho, Hyung-Rae
Yang, Kun-Ju
Moon, Seung-Bae
Park, Bok-Ryeon
Shin, Hyun-Dong
Jang, Hee-Jeong
Kim, Lin-Su
Ku, Sae-Kwang
author_sort Lee, Hyeung-Sik
collection PubMed
description In this research the genotoxic effect of Polycan™ β-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. Polycan™ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that Polycan™ shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of Polycan™ tested in this study because the polychromatic erythrocyte ratio was detected as > 0.47 in all tested groups.
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spelling pubmed-70063442020-02-07 Micronucleus Test of Polycan™, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice Lee, Hyeung-Sik Cho, Hyung-Rae Yang, Kun-Ju Moon, Seung-Bae Park, Bok-Ryeon Shin, Hyun-Dong Jang, Hee-Jeong Kim, Lin-Su Ku, Sae-Kwang Toxicol Res Article In this research the genotoxic effect of Polycan™ β-glucans originated from Aureobasidium pullulans SM-2001, was evaluated using the mouse micronucleus test. Polycan™ was administered once a day for 2 days by oral gavage to male ICR mice at doses of 1000, 500 and 250 mg/kg. Cyclophosphamide was used as a known genotoxic agent in a positive control group. The appearance of a micronucleus is used as an index for genotoxic potential. The results obtained indicated that Polycan™ shows no genotoxicity effect up to 1000 mg/kg dosing levels. In addition, it is also considered that there were no problems from cytotoxicity of Polycan™ tested in this study because the polychromatic erythrocyte ratio was detected as > 0.47 in all tested groups. Springer Singapore 2008-03-01 2008-03 /pmc/articles/PMC7006344/ /pubmed/32038771 http://dx.doi.org/10.5487/TR.2008.24.1.011 Text en © Korean Society of Toxicology 2008 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lee, Hyeung-Sik
Cho, Hyung-Rae
Yang, Kun-Ju
Moon, Seung-Bae
Park, Bok-Ryeon
Shin, Hyun-Dong
Jang, Hee-Jeong
Kim, Lin-Su
Ku, Sae-Kwang
Micronucleus Test of Polycan™, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice
title Micronucleus Test of Polycan™, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice
title_full Micronucleus Test of Polycan™, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice
title_fullStr Micronucleus Test of Polycan™, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice
title_full_unstemmed Micronucleus Test of Polycan™, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice
title_short Micronucleus Test of Polycan™, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice
title_sort micronucleus test of polycan™, β-glucan originated from aureobasidium, in bone marrow cells of male icr mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006344/
https://www.ncbi.nlm.nih.gov/pubmed/32038771
http://dx.doi.org/10.5487/TR.2008.24.1.011
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