Purifying selection of long dsRNA is the first line of defense against false activation of innate immunity

BACKGROUND: Mobile elements comprise a large fraction of metazoan genomes. Accumulation of mobile elements is bound to produce multiple putative double-stranded RNA (dsRNA) structures within the transcriptome. These endogenous dsRNA structures resemble viral RNA and may trigger false activation of t...

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Detalles Bibliográficos
Autores principales: Barak, Michal, Porath, Hagit T., Finkelstein, Gilad, Knisbacher, Binyamin A., Buchumenski, Ilana, Roth, Shalom Hillel, Levanon, Erez Y., Eisenberg, Eli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006430/
https://www.ncbi.nlm.nih.gov/pubmed/32028986
http://dx.doi.org/10.1186/s13059-020-1937-3

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