Rational design of a DNA sequence-specific modular protein tag by tuning the alkylation kinetics

Sequence-selective chemical modification of DNA by synthetic ligands has been a long-standing challenge in the field of chemistry. Even when the ligand consists of a sequence-specific DNA binding domain and reactive group, sequence-selective reactions by these ligands are often accompanied by off-ta...

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Detalles Bibliográficos
Autores principales: Nguyen, Thang Minh, Nakata, Eiji, Zhang, Zhengxiao, Saimura, Masayuki, Dinh, Huyen, Morii, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006624/
https://www.ncbi.nlm.nih.gov/pubmed/32110294
http://dx.doi.org/10.1039/c9sc02990g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006624/
https://www.ncbi.nlm.nih.gov/pubmed/32110294
http://dx.doi.org/10.1039/c9sc02990g

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