Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists

A series of nitrogen heterocycles containing α–ethoxyphenylpropionic acid derivatives were designed as dual PPARα/γ agonist ligands for the treatment of type 2 diabetes (T2D) and its complications. 6-Benzoyl-benzothiazol-2-one was the most tolerant of the tested heterocycles in which incorporation o...

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Detalles Bibliográficos
Autores principales: Hurtevent, Aurélie, Le Naour, Morgan, Leclerc, Veronique, Carato, Pascal, Melnyk, Patricia, Hennuyer, Nathalie, Staels, Bart, Beucher-Gaudin, Monique, Caignard, Daniel-Henri, Dacquet, Catherine, Lebegue, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006651/
https://www.ncbi.nlm.nih.gov/pubmed/31939313
http://dx.doi.org/10.1080/14756366.2020.1713771

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