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6mA-RicePred: A Method for Identifying DNA N (6)-Methyladenine Sites in the Rice Genome Based on Feature Fusion

MOTIVATION: The biological function of N (6)-methyladenine DNA (6mA) in plants is largely unknown. Rice is one of the most important crops worldwide and is a model species for molecular and genetic studies. There are few methods for 6mA site recognition in the rice genome, and an effective computati...

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Detalles Bibliográficos
Autores principales: Huang, Qianfei, Zhang, Jun, Wei, Leyi, Guo, Fei, Zou, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006724/
https://www.ncbi.nlm.nih.gov/pubmed/32076430
http://dx.doi.org/10.3389/fpls.2020.00004
Descripción
Sumario:MOTIVATION: The biological function of N (6)-methyladenine DNA (6mA) in plants is largely unknown. Rice is one of the most important crops worldwide and is a model species for molecular and genetic studies. There are few methods for 6mA site recognition in the rice genome, and an effective computational method is needed. RESULTS: In this paper, we propose a new computational method called 6mA-Pred to identify 6mA sites in the rice genome. 6mA-Pred employs a feature fusion method to combine advantageous features from other methods and thus obtain a new feature to identify 6mA sites. This method achieved an accuracy of 87.27% in the identification of 6mA sites with 10-fold cross-validation and achieved an accuracy of 85.6% in independent test sets.